Mortality among patients with chronic kidney disease (CKD) is largely a consequence of
cardiovascular disease (CVD) and is a particular concern given the increasing prevalence of …

Pyroptosis is a necrotic form of regulated cell death. Gasdermines (GSDMs) are a family of
intracellular proteins that execute pyroptosis. While GSDMs are expressed as inactive forms …

A defining property of cytotoxic lymphocytes is their expression and regulated secretion of
potent toxins, including the pore-forming protein perforin and serine protease granzymes …

Inflammation occurs after disruption of tissue homeostasis by cell stress, injury or infection
and ultimately involves the recruitment and retention of cells of hematopoietic origin, which …

Our immune system is based on the close collaboration of the innate and adaptive immune
systems for the rapid detection of any threats to the host. Recognition of pathogen-derived …

Objective—Coronary artery thrombosis can occur in the absence of plaque rupture because
of superficial erosion. Erosion-prone atheromata associate with more neutrophil …

The extracellular forms of the IL‐1 cytokines are active through binding to specific receptors
on the surface of target cells. IL‐1 ligands bind to the extracellular portion of their ligand …

The three-signal paradigm tries to capture how the innate immune system instructs adaptive
immune responses in three well-defined actions:(1) presentation of antigenic peptides in the …

Summary The interleukin (IL)‐1 family of cytokines is currently comprised of 11 members
that have pleiotropic functions in inflammation and cancer. IL‐1α and IL‐1β were the first …

Members of the extended interleukin-1 (IL-1) cytokine family, such as IL-1, IL-18, IL-33, and
IL-36, play a pivotal role in the initiation and amplification of immune responses. However …