A family history of hip fracture carries a twofold increased risk of fracture among
descendants. Genetic factors indeed play a major role in the determination of bone mineral …

Osteoporosis is characterized by low bone mineral density and structural deterioration of
bone tissue, leading to an increased risk of fractures. It is the most common metabolic bone …

Osteoporosis is a complex and heterogeneous disorder, of multi-factor aetiology. It is the
most frequent metabolic bone disorder, affecting an increasing number of post-menopausal …

Osteoporosis is an important and complex disorder that is highly prevalent worldwide. This
disease poses a major challenge to modern medicine and its treatment is associated with …

Bone mineral density (BMD) is a complex and highly hereditary trait that can lead to
osteoporotic fractures. It is estimated that BMD is mainly affected by genetic factors (about …

To scan novel candidate genes associated with osteoporosis, a two-stage transcriptome-
wide association study (TWAS) of bone mineral density (BMD) was conducted. The BMD …

Previous data from our group indicate that BMD is linked to chromosome 3p14–p21.
Because the filamin B (FLNB gene resides in this region, is the cause of skeletal dysplasias …

Genome-wide association studies (GWAS) using high-density array of single-nucleotide
polymorphisms (SNPs) offer an unbiased strategy to identify new candidate genes for …

In contemporary populations, pregnancy and lactation are usually followed by transient
bone loss. The observation of reduced bone mass in young females from archaeological …

OBJECTIVE: Genetic factors determine bone mineral density (BMD) and peak bone density
between 20 and 30 years of age, as well as bone mineral loss after menopause. BMD is a …