A brief introduction to chemical reaction optimization

CJ Taylor, A Pomberger, KC Felton, R Grainger… - Chemical …, 2023 - ACS Publications
From the start of a synthetic chemist's training, experiments are conducted based on recipes
from textbooks and manuscripts that achieve clean reaction outcomes, allowing the scientist …

Nanotechnology based approaches for enhancing oral bioavailability of poorly water soluble antihypertensive drugs

M Sharma, R Sharma, DK Jain - Scientifica, 2016 - Wiley Online Library
Oral administration is the most convenient route among various routes of drug delivery as it
offers high patient compliance. However, the poor aqueous solubility and poor …

Response surface methodology optimization of mono-dispersed MgO nanoparticles fabricated by ultrasonic-assisted sol–gel method for outstanding antimicrobial and …

CW Wong, YS Chan, J Jeevanandam, K Pal… - Journal of Cluster …, 2020 - Springer
Magnesium oxide (MgO) nanoparticles are one of the highly significant compounds in
construction. The novelty concentrated on using sol–gel technique coupled with …

Catalytic performance of MgO/Fe2O3-SiO2 core-shell magnetic nanocatalyst for biodiesel production of Camelina sativa seed oil: Optimization by RSM-CCD method

T Rahimi, D Kahrizi, M Feyzi, HR Ahmadvandi… - Industrial Crops and …, 2021 - Elsevier
Many investigations have introduced MgO as a favorable solid base catalyst. Although
magnesium oxide catalyst does not have as strong of basic sites as calcium oxide catalyst, it …

Formulation, optimization and characterization of allantoin-loaded chitosan nanoparticles to alleviate ethanol-induced gastric ulcer: in-vitro and in-vivo studies

RM Aman, RA Zaghloul, MS El-Dahhan - Scientific reports, 2021 - nature.com
Allantoin (ALL) is a phytochemical possessing an impressive array of biological activities.
Nonetheless, developing a nanostructured delivery system targeted to augment the gastric …

Drilling into “Quality by Design” approach for analytical methods

L Chiarentin, C Gonçalves, C Augusto… - Critical Reviews in …, 2023 - Taylor & Francis
The need for consistency in analytical method development reinforces the dependence of
pharmaceutical product development and manufacturing on robust analytical data. The …

A quality by design approach on polymeric nanocarrier delivery of gefitinib: formulation, in vitro, and in vivo characterization

NS Kola Srinivas, R Verma, G Pai Kulyadi… - International journal of …, 2017 - Taylor & Francis
Gefitinib is an anticancer agent which acts by inhibiting epidermal growth factor receptor
tyrosine kinase receptors. The aim of the present study was to prepare gefitinib …

Analytical 'Quality-by-Design'paradigm in development of a RP-HPLC method for the estimation of cilnidipine in nanoformulations: Forced degradation studies and …

SM Marques, RK Shirodkar, L Kumar - Microchemical Journal, 2023 - Elsevier
The present study focuses on optimizing, developing, and validating a sensitive and specific
reversed-phase high-performance liquid chromatography (RP-HPLC) method for the …

Green analytical chemistry and experimental design: a combined approach for the analysis of zonisamide

SG Elsheikh, AME Hassan, YM Fayez… - BMC chemistry, 2023 - Springer
Green analytical chemistry principles, as well as experimental design, are a combined
approach adopted to develop sensitive reproducible stability indicating HPLC method for …

Investigation of Alogliptin-Loaded In Situ Gel Implants by 23 Factorial Design with Glycemic Assessment in Rats

TM Ibrahim, MM Ayoub, HM El-Bassossy, HM El-Nahas… - Pharmaceutics, 2022 - mdpi.com
The aim of the study was to design injectable long-acting poly (lactide-co-glycolide)(PLGA)-
based in situ gel implants (ISGI) loaded with the anti-diabetic alogliptin. Providing sustained …