Tetrahydrobiopterin (BH4) is an endogenous cofactor for some enzymatic conversions of
essential biomolecules, including nitric oxide, and monoamine neurotransmitters, and for the …

SUMMARY Riboflavin [7, 8-dimethyl-10-(1′-d-ribityl) isoalloxazine, vitamin B2] is an
obligatory component of human and animal diets, as it serves as the precursor of flavin …

Dystonias comprise a group of movement disorders that are characterized by involuntary
movements and postures. Insight into the nature of neuronal dysfunction has been provided …

NO produced by eNOS (endothelial nitric oxide synthase) is a key mediator of vascular
homoeostasis. NO bioavailability is reduced early in vascular disease states, such as …

The biosynthesis of one riboflavin molecule requires one molecule of GTP and two
molecules of ribulose 5-phosphate. The imidazole ring of GTP is hydrolytically opened …

Ionizing radiation and radioactive materials have been widely used in industry, medicine,
science and military. The efficacy of radiotherapy and adverse effects of normal tissues are …

Newborn neurons enter an extended maturation stage, during which they acquire excitability
characteristics crucial for development of presynaptic and postsynaptic connectivity. In …

(6R)-5, 6, 7, 8-Tetrahydrobiopterin (BH4) is an endogenously produced pterin that is found
widely distributed in mammalian tissues. BH4 works as a cofactor of aromatic amino acid …

Protein–protein interfaces are often stabilized by a small number of dominant contacts,
exemplified by the overrepresentation of arginine residues at oligomerization interfaces …

Resistance to antimalarials targeting the folate pathway is widespread. GTP‐cyclohydrolase
(gch1), the first enzyme in this pathway, exhibits extensive copy number variation (CN) in …