Current data regarding the structure-toxicity relationship of boron-containing compounds

ED Farfán-García, NT Castillo-Mendieta… - Toxicology letters, 2016 - Elsevier
Boron is ubiquitous in nature, being an essential element of diverse cells. As a result,
humans have had contact with boron containing compounds (BCCs) for a long time. During …

Advances in theoretical studies on the design of single boron atom compounds

M Bello - Current Pharmaceutical Design, 2018 - ingentaconnect.com
Background: Single Boron Atom Compounds (SBACs) have been used for drug discovery in
diseaseassociated proteins due to the empty p-orbital in the atomic structure of boron, which …

Borinostats: solid-phase synthesis of carborane-capped histone deacetylase inhibitors with a tailor-made selectivity profile

C Selg, A Schöler, J Schliehe-Diecks, M Hanl… - Chemical …, 2021 - pubs.rsc.org
The elevated expression of histone deacetylases (HDACs) in various tumor types renders
their inhibition an attractive strategy for epigenetic therapeutics. One key issue in the …

Screening of commercial cyclic peptide conjugated to HIV-1 Tat peptide as inhibitor of N-terminal heptad repeat glycoprotein-2 ectodomain Ebola virus through in …

USF Tambunan, AH Alkaff, MAF Nasution… - Journal of Molecular …, 2017 - Elsevier
Abstract Ebola Hemorrhagic Fever (EHF) is a disease caused by viruses from genus
Ebolavirus. Zaire ebolavirus (EBOV) is the deadliest species which has 76% case fatality …

Modification of S-Adenosyl-l-Homocysteine as Inhibitor of Nonstructural Protein 5 Methyltransferase Dengue Virus Through Molecular Docking and Molecular …

USF Tambunan, MAF Nasution, F Azhima… - Drug Target …, 2017 - journals.sagepub.com
Dengue fever is still a major threat worldwide, approximately threatening two-fifths of the
world's population in tropical and subtropical countries. Nonstructural protein 5 (NS5) …

Identification of novel Ebola virus (EBOV) VP24 inhibitor from Indonesian natural products through in silico drug design approach

USF Tambunan, MAF Nasution - AIP Conference Proceedings, 2017 - pubs.aip.org
Ebola remains as one of the deadliest diseases in the world, with almost 29,000 cases were
reported and kill 11,000 of them, and yet neither treatment nor vaccine that can combat this …

Vaccine design for H5N1 based on B-and T-cell epitope predictions

USF Tambunan, FRP Sipahutar… - … and Biology insights, 2016 - journals.sagepub.com
From 2003 to 2013, Indonesia had the highest number of avian influenza A cases in
humans, with 192 cases and 160 fatalities. Avian influenza is caused by influenza virus type …

[HTML][HTML] Exposing the molecular screening method of Indonesian natural products derivate as drug candidates for cervical cancer

USF Tambunan, AA Parikesit… - Iranian journal of …, 2017 - ncbi.nlm.nih.gov
The menace of cervical cancer has reached an alarming rate. There are more than 450.000
cases of cervical cancer yearly, with mortality rate of about 50%. This deadly cancer is …

Histone deacetylase 2 (HDAC2) inhibitors containing boron

P Kavianpour, MCM Gemmell, JU Kahlert… - …, 2020 - Wiley Online Library
Histone deacetylase enzymes (HDACs) are responsible for the global silencing of tumour‐
suppressor genes. Treatment with a histone deacetylase inhibitor (HDACi) can reverse this …

[PDF][PDF] Pemanfaatan bioinformatika dalam bidang pertanian dan kesehatan

AA Parikesit, A Dito, AP Riza - E-Journal Menara Perkebunan, 2017 - academia.edu
Bioinformatika dapat digunakan dalam manajemen informasi di bidang penyimpanan data
in silico dari eksperimen biologi molekuler. Aplikasi luar jaringan (luring) memerlukan …