Identification of GBF1 as a cellular factor required for hepatitis E virus RNA replication
R Farhat, M Ankavay, N Lebsir… - Cellular …, 2018 - Wiley Online Library
The hepatitis E virus (HEV) genome is a single‐stranded, positive‐sense RNA that encodes
three proteins including the ORF1 replicase. Mechanisms of HEV replication in host cells are …
three proteins including the ORF1 replicase. Mechanisms of HEV replication in host cells are …
Structural and functional analysis of the small GTPase ARF1 reveals a pivotal role of its GTP-binding domain in controlling of the generation of viral inclusion bodies …
J Zhang, P Li, R Lu, S Ouyang, MX Chang - Frontiers in Immunology, 2022 - frontiersin.org
Grass carp reovirus (GCRV) is the most pathogenic double-stranded (ds) RNA virus among
the isolated aquareoviruses. The molecular mechanisms by which GCRV utilizes host …
the isolated aquareoviruses. The molecular mechanisms by which GCRV utilizes host …
The development of resistance to an inhibitor of a cellular protein reveals a critical interaction between the enterovirus protein 2C and a small GTPase Arf1
The cellular protein GBF1, an activator of Arf GTPases (ArfGEF: Arf guanine nucleotide
exchange factor), is recruited to the replication organelles of enteroviruses through …
exchange factor), is recruited to the replication organelles of enteroviruses through …
A redundant mechanism of recruitment underlies the remarkable plasticity of the requirement of poliovirus replication for the cellular ArfGEF GBF1
EG Viktorova, S Gabaglio, JM Meissner, E Lee… - Journal of …, 2019 - Am Soc Microbiol
The replication of many positive-strand RNA viruses [(+) RNA viruses] depends on the
cellular protein GBF1, but its role in the replication process is not clear. In uninfected cells …
cellular protein GBF1, but its role in the replication process is not clear. In uninfected cells …
[HTML][HTML] Modulation of proteolytic polyprotein processing by coxsackievirus mutants resistant to inhibitors targeting phosphatidylinositol-4-kinase IIIβ or oxysterol …
H Lyoo, CM Dorobantu, HM van der Schaar… - Antiviral Research, 2017 - Elsevier
Enteroviruses (eg poliovirus, coxsackievirus, and rhinovirus) require several host factors for
genome replication. Among these host factors are phosphatidylinositol-4-kinase IIIβ (PI4KB) …
genome replication. Among these host factors are phosphatidylinositol-4-kinase IIIβ (PI4KB) …
Rab1b-GBF1-ARFs mediated intracellular trafficking is required for classical swine fever virus replication in swine umbilical vein endothelial cells
L Zhang, T Wang, M Song, M Jin, S Liu, K Guo… - Veterinary …, 2020 - Elsevier
Classical swine fever virus (CSFV), a plus-sense RNA virus, utilizes host intracellular
membrane organelles for its replication. Our previous studies have shown that disruption of …
membrane organelles for its replication. Our previous studies have shown that disruption of …
In vitro activity of the novel pyrimidines and their condensed derivatives against poliovirus
R Solomyannyi, S Slivchuk, D Smee… - Current Bioactive …, 2019 - ingentaconnect.com
Background: Substituted pyrimidine derivatives (non-nucleoside) are found to be associated
with various biological activities. The various substituted pyrimidines are also having …
with various biological activities. The various substituted pyrimidines are also having …
AG1478 elicits a novel anti-influenza function via an EGFR-independent, GBF1-dependent pathway
Current options for preventing or treating influenza are still limited, and new treatments for
influenza viral infection are urgently needed. In the present study, we serendipitously found …
influenza viral infection are urgently needed. In the present study, we serendipitously found …
Trends in antiviral strategies
E Domingo - Virus as Populations, 2019 - pmc.ncbi.nlm.nih.gov
Viral populations are true moving targets regarding the genomic sequences to be targeted in
antiviral designs. Experts from different fields have expressed the need for new paradigms …
antiviral designs. Experts from different fields have expressed the need for new paradigms …
Characterization of the GBF1-Arf1 Axis in Enterovirus RNA Replication
SMG Velazquez - 2024 - search.proquest.com
The Enterovirus genus includes many known and emerging pathogens, such as poliovirus,
enteroviruses A71 and D68, rhinoviruses, and others. Enterovirus infection induces the …
enteroviruses A71 and D68, rhinoviruses, and others. Enterovirus infection induces the …