Physiological limitations and opportunities in microbial metabolic engineering

J Montaño López, L Duran, JL Avalos - Nature Reviews Microbiology, 2022 - nature.com
Metabolic engineering can have a pivotal role in increasing the environmental sustainability
of the transportation and chemical manufacturing sectors. The field has already developed …

Engineered methanotrophy: a sustainable solution for methane-based industrial biomanufacturing

AD Nguyen, EY Lee - Trends in Biotechnology, 2021 - cell.com
Methane is a promising feedstock with high abundance and low cost for the sustainable
production of biochemicals and biofuels. Methanotrophic bacteria are particularly interesting …

Awakening a latent carbon fixation cycle in Escherichia coli

A Satanowski, B Dronsella, E Noor, B Vögeli… - Nature …, 2020 - nature.com
Carbon fixation is one of the most important biochemical processes. Most natural carbon
fixation pathways are thought to have emerged from enzymes that originally performed other …

The oxygen-tolerant reductive glycine pathway assimilates methanol, formate and CO2 in the yeast Komagataella phaffii

BM Mitic, C Troyer, L Lutz, M Baumschabl… - Nature …, 2023 - nature.com
The current climatic change is predominantly driven by excessive anthropogenic CO2
emissions. As industrial bioprocesses primarily depend on food-competing organic …

Engineering a new-to-nature cascade for phosphate-dependent formate to formaldehyde conversion in vitro and in vivo

M Nattermann, S Wenk, P Pfister, H He, SH Lee… - Nature …, 2023 - nature.com
Formate can be envisioned at the core of a carbon-neutral bioeconomy, where it is produced
from CO2 by (electro-) chemical means and converted into value-added products by …

Turn air-captured CO2 with methanol into amino acid and pyruvate in an ATP/NAD(P)H-free chemoenzymatic system

J Liu, H Zhang, Y Xu, H Meng, AP Zeng - Nature Communications, 2023 - nature.com
The use of gaseous and air-captured CO2 for technical biosynthesis is highly desired, but
elusive so far due to several obstacles including high energy (ATP, NADPH) demand, low …

Chemistry in times of artificial intelligence

J Gasteiger - ChemPhysChem, 2020 - Wiley Online Library
Chemists have to a large extent gained their knowledge by doing experiments and thus
gather data. By putting various data together and then analyzing them, chemists have …

Challenges and opportunities in C1-based biomanufacturing

W Qiao, S Xu, Z Liu, X Fu, H Zhao, S Shi - Bioresource Technology, 2022 - Elsevier
The intensifying impact of green-house gas (GHG) emission on environment and climate
change has attracted increasing attention, and biorefinery represents one of the most …

Recent advances toward the bioconversion of methane and methanol in synthetic methylotrophs

GJ Gregory, RK Bennett, ET Papoutsakis - Metabolic Engineering, 2022 - Elsevier
Abundant natural gas reserves, along with increased biogas production, have prompted
recent interest in harnessing methane as an industrial feedstock for the production of liquid …

Methanotrophs: Metabolic versatility from utilization of methane to multi-carbon sources and perspectives on current and future applications

HTQ Le, EY Lee - Bioresource Technology, 2023 - Elsevier
The development of biorefineries for a sustainable bioeconomy has been driven by the
concept of utilizing environmentally friendly and cost-effective renewable energy sources …