B-precursor acute lymphoblastic leukemia (B-ALL) is the most common childhood tumor and
the leading cause of cancer-related death in children and young adults. The majority of B …

Acute lymphoblastic leukaemia (ALL) occurs at all ages but is the most common cancer of
childhood. The current treatment of paediatric ALL is highly successful with up to 90 …

Leukemia in infants is rare but generates tremendous interest due to its aggressive clinical
presentation in a uniquely vulnerable host, its poor response to current therapies, and its …

Infant acute leukaemia is characterised by specific genetic rearrangements and a rapid
onset of disease shortly after birth. The vast majority of these cases bear rearranged MLL …

Infant B-cell acute lymphoblastic leukemia (B-ALL) accounts for 10% of childhood ALL. The
genetic hallmark of most infant B-ALL is chromosomal rearrangements of the mixed-lineage …

Summary The Mixed Lineage Leukemia (MLL) protein is an important epigenetic regulator
required for the maintenance of gene activation during development. MLL chromosomal …

B cell leukaemia is one of the most frequent malignancies in the paediatric population, but
also affects a significant proportion of adults in developed countries. The majority of infant …

Gene expression profiling was performed on 97 cases of infant ALL from Children's
Oncology Group Trial P9407. Statistical modeling of an outcome predictor revealed 3 genes …

Fusion oncogenes are prevalent in several pediatric cancers, yet little is known about the
specific associations between age and phenotype. We observed that fusion oncogenes …

Infant acute lymphoblastic leukemia harboring the fusion mixed-lineage leukemia (MLL)-
AF4 is associated with a dismal prognosis and very brief latency. Our limited understanding …