Diabetic nephropathy is a significant cause of chronic kidney disease and end-stage renal
failure globally. Much research has been conducted in both basic science and clinical …

The renin-angiotensin system has powerful effects in control of the blood pressure and
sodium homeostasis. These actions are coordinated through integrated actions in the …

Renin angiotensin system (RAS) is known to play a key role in several diseases such as
diabetes, and renal and cardiovascular pathologies. Its blockade has been demonstrated to …

Diabetic nephropathy is a major cause of ESRD worldwide. Despite its prevalence, a lack of
reliable animal models that mimic human disease has delayed the identification of specific …

Abstract Angiotensin-converting enzyme 2 (ACE2) expression has been shown to be altered
in renal tubules from diabetic mice. This study examined the localization of ACE and ACE2 …

The renin–angiotensin–aldosterone system (RAAS) is a key regulator of systemic blood
pressure and renal function and a key player in renal and cardiovascular disease. However …

Diabetes is a worldwide epidemic that has led to a rise in diabetic kidney disease (DKD).
Over the past two decades, there has been significant clarification of the various pathways …

Inhibition of the renin-angiotensin-aldosterone system (RAAS) is one of the most powerful
maneuvers to slow progression of renal disease. Angiotensin II (AngII) has emerged in the …

Angiotensin converting enzyme (ACE) plays an essential role in two physiological systems,
one leading to the production of angiotensin II and the other to the degradation of …

Mice provide an experimental model of unparalleled flexibility for studying mammalian
diseases. Inbred strains of mice exhibit substantial differences in their susceptibility to the …