Human Vγ2Vδ2 T cells play important roles in mediating immunity against microbial
pathogens and have potent anti‐tumor activity. Vγ2Vδ2 T cells recognize the …

The tumor immune microenvironment contributes to tumor initiation, progression, and
response to therapy. Among the immune cell subsets that play a role in the tumor …

In innate immune responses, activation of Toll-like receptors (TLRs) triggers direct
antimicrobial activity against intracellular bacteria, which in murine, but not human …

Host defense against intracellular pathogens depends upon innate and adaptive
antimicrobial effector pathways. TLR2/1-activation of monocytes leads to the vitamin D …

Abstract Vγ2Vδ2 T cells comprise 2%–5% of human peripheral blood T cells, recognize
ubiquitous nonpeptide antigens, and expand up to 50-fold during microbial infection. It is not …

Protective immunity against Mycobacterium tuberculosis requires the generation of cell-
mediated immunity. We investigated the expression and role of programmed death 1 (PD-1) …

Human γδ T cells expressing the Vγ2Vδ2 TCR play important roles in immune responses to
microbial pathogens by monitoring prenyl pyrophosphate isoprenoid metabolites. Most adult …

Abstract γδT cells are a conserved population of innate lymphocytes with diverse structural
and functional heterogeneity that participate in various immune responses during tumor …

We have recently described a highly sensitive flow cytometric technique, based on the ability
to detect single cell expression of cytokines, to simultaneously quantitate and phenotypically …

The identification of distinct T helper lymphocyte subsets (Th1/2) with polarised cytokine
production has opened up new fields in immunobiology. Of the several alternative methods …