Pathogenesis of Important Virulence Factors of Porphyromonas gingivalis via Toll-Like Receptors

L Jia, N Han, J Du, L Guo, Z Luo, Y Liu - Frontiers in cellular and …, 2019 - frontiersin.org
Periodontitis is a common intraoral infection and is inextricably linked to systemic diseases.
Recently, the regulation between host immunologic response and periodontal pathogens …

Small-molecule modulators of toll-like receptors

Y Wang, S Zhang, H Li, H Wang, T Zhang… - Accounts of chemical …, 2020 - ACS Publications
Conspectus Toll-like receptors (TLRs) are the “gatekeepers” of the immune system in
humans and other animals to protect the host from invading bacteria, viruses, and other …

TLR2 and TLR4 in Parkinson's disease pathogenesis: The environment takes a toll on the gut

AM Gorecki, CC Anyaegbu, RS Anderton - Translational …, 2021 - Springer
Parkinson's disease (PD) is an incurable, devastating disorder that is characterized by
pathological protein aggregation and neurodegeneration in the substantia nigra. In recent …

Pathogenic Mechanisms and Host Interactions in Staphylococcus epidermidis Device-Related Infection

M Sabaté Brescó, LG Harris, K Thompson… - Frontiers in …, 2017 - frontiersin.org
Staphylococcus epidermidis is a permanent member of the normal human microbiota,
commonly found on skin and mucous membranes. By adhering to tissue surface moieties of …

Toll-like receptor 2 is increased in neurons in Parkinson's disease brain and may contribute to alpha-synuclein pathology

N Dzamko, A Gysbers, G Perera, A Bahar… - Acta …, 2017 - Springer
Inflammation is likely a key contributor to the pathogenesis of Parkinson's disease (PD), a
progressively debilitating neurodegenerative disease that is accompanied by a pathological …

TLR-dependent human mucosal epithelial cell responses to microbial pathogens

R McClure, P Massari - Frontiers in immunology, 2014 - frontiersin.org
Toll-like receptor (TLR) signaling represents one of the best studied pathways to implement
defense mechanisms against invading microbes in human being as well as in animals …

Innate immune system activation, inflammation and corneal wound healing

N Fortingo, S Melnyk, SH Sutton, MA Watsky… - International journal of …, 2022 - mdpi.com
Corneal wounds resulting from injury, surgeries, or other intrusions not only cause pain, but
also can predispose an individual to infection. While some inflammation may be beneficial to …

Immune defenses of the mammary gland epithelium of dairy ruminants

P Rainard, FB Gilbert, P Germon - Frontiers in immunology, 2022 - frontiersin.org
The epithelium of the mammary gland (MG) fulfills three major functions: nutrition of progeny,
transfer of immunity from mother to newborn, and its own defense against infection. The …

Extracellular vesicles produced by the human gut commensal bacterium Bacteroides thetaiotaomicron elicit anti-inflammatory responses from innate immune cells

S Fonseca, AL Carvalho, A Miquel-Clopés… - Frontiers in …, 2022 - frontiersin.org
Bacterial extracellular vesicles (BEVs) produced by gut commensal bacteria have been
proposed to play an important role in maintaining host homeostasis via interactions with the …

Sensing of Mycobacterium tuberculosis and consequences to both host and bacillus

CE Stamm, AC Collins, MU Shiloh - Immunological reviews, 2015 - Wiley Online Library
Mycobacterium tuberculosis (Mtb), the primary causative agent of human tuberculosis, has
killed more people than any other bacterial pathogen in human history and remains one of …