Background: The Canadian Network for Mood and Anxiety Treatments (CANMAT)
conducted a revision of the 2009 guidelines by updating the evidence and …

A systematic review and random-effects model network meta-analysis were conducted to
compare the efficacy, acceptability, tolerability, and safety of antidepressants to treat adults …

Objectives: To provide advice and guidance regarding the management of mood disorders,
derived from scientific evidence and supplemented by expert clinical consensus to formulate …

Background Many depressed patients are not able to achieve or sustain symptom remission
despite serial treatment trials–often termed “treatment resistant depression”. A broader …

Background: The Canadian Network for Mood and Anxiety Treatments (CANMAT)
conducted a revision of the 2009 guidelines by updating the evidence and …

Cognitive dysfunction is a symptomatic domain identified across many mental disorders.
Cognitive deficits in individuals with major depressive disorder (MDD) contribute …

Background Multiple treatments are effective for major depressive disorder (MDD), but the
outcomes of each treatment vary broadly among individuals. Accurate prediction of …

Millions of people globally have learned mindfulness meditation with the goal of improving
health and well-being outcomes in both clinical and non-clinical contexts. An estimated half …

Background Treatment‐resistant depression (TRD) is a debilitating chronic mental illness
that confers increased morbidity and mortality, decreases the quality of life, impairs …

Objective Serotonergic psychedelics are re-emerging as potential novel treatments for
several psychiatric disorders including major depressive disorder. The Canadian Network …