Much like solving a game of Clue, understanding physiological mysteries involves
answering who, what, when and where. Multiomics approaches delve into cellular and …

The past decade has witnessed a revolution in cancer treatment by the shift from
conventional drugs (chemotherapies) towards targeted molecular therapies and immune …

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the commonest cause
of chronic liver disease worldwide and represents an unmet precision medicine challenge …

Tissues are complex environments where different cell types are in constant interaction with
each other and with non-cellular components. Preserving the spatial context during …

Allograft rejection is common following clinical organ transplantation, but defining specific
immune subsets mediating alloimmunity has been elusive. Calcineurin inhibitor dose …

Immunotherapy plays a key role in cancer treatment, however, responses are limited to a
small number of patients. The biological basis for the success of immunotherapy is the …

Dysregulated lipid metabolism in obesity leads to adipose tissue expansion, a major
contributor to metabolic dysfunction and chronic disease. Lipid metabolism and fatty acid …

The field of oncology has been transformed by immune checkpoint inhibitors (ICI) and other
immune-based agents; however, many patients do not receive a durable benefit. While …

Growing evidence supports the critical role of tumour microenvironment (TME) in tumour
progression, metastases, and treatment response. However, the in-situ interplay among …

Advances in single-cell technologies have transformed the ability to identify the individual
cell types present within tissues and organs. The musculoskeletal bionetwork, part of the …