[HTML][HTML] Critical assessment of structure-based approaches to improve protein resistance in aqueous ionic liquids by enzyme-wide saturation mutagenesis
Ionic liquids (IL) and aqueous ionic liquids (aIL) are attractive (co-) solvents for green
industrial processes involving biocatalysts, but often reduce enzyme activity. Experimental …
industrial processes involving biocatalysts, but often reduce enzyme activity. Experimental …
Effects of point mutations on the thermostability of B. subtilis lipase: investigating nonadditivity
Molecular level understanding of mutational effects on stability and activity of enzymes is
challenging particularly when several point mutations are incorporated during the directed …
challenging particularly when several point mutations are incorporated during the directed …
Characterization of recombinant endo-1,4-β-xylanase of Bacillus halodurans C-125 and rational identification of hot spot amino acid residues responsible for …
Increased demand of enzymes for industrial use has led the scientists towards protein
engineering techniques. In different protein engineering strategies, rational approach has …
engineering techniques. In different protein engineering strategies, rational approach has …
Enhancement of hydrogen peroxide tolerance of lipase LipA from Bacillus subtilis using semi-rational design
H Jiang, W Jia, M Duan, H Lin, J Huang, X Li… - Biochemical engineering …, 2020 - Elsevier
In many application fields, microbial lipases have to coexist with hydrogen peroxide in the
same reaction system and it is necessary to construct hydrogen peroxide-tolerant lipase …
same reaction system and it is necessary to construct hydrogen peroxide-tolerant lipase …
Identification of effective dimeric gramicidin-D peptide as antimicrobial therapeutics over drug resistance: in-silico approach
G Pavithrra, R Rajasekaran - Interdisciplinary Sciences: Computational …, 2019 - Springer
Discovering and developing the antimicrobial peptides are recently focused on
pharmaceutical firm, since they serve as complementary to antibiotics in prevailing over drug …
pharmaceutical firm, since they serve as complementary to antibiotics in prevailing over drug …
Structural stability among hybrid antimicrobial peptide cecropin A (1–8)–magainin 2 (1–12) and its analogues: a computational approach
B Senthilkumar, D Meshach Paul, E Srinivasan… - Journal of Cluster …, 2017 - Springer
Abstract Cecropin A–Magainin 2 (CA–MA) hybrid antimicrobial peptide (AMP), a
combination of two naturally occurring AMPs, cecropin A and magainin 2 is preferred widely …
combination of two naturally occurring AMPs, cecropin A and magainin 2 is preferred widely …
Screening of Pathogenic Missense Single Nucleotide Variants From LHPP Gene Associated With the Hepatocellular Carcinoma: An In silico Approach
MS Mahmood, M Afzal, H Batool… - … and Biology Insights, 2022 - journals.sagepub.com
LHPP gene encodes a phospholysine phosphohistidine inorganic pyrophosphate
phosphatase, which functions as a tumor-suppressor protein. The tumor suppression by this …
phosphatase, which functions as a tumor-suppressor protein. The tumor suppression by this …
High yield expression, characterization, and biological activity of IFNα2-Tα1 fusion protein
The use of interferon α-2 in combination with thymosin α-1 shows higher anti-cancer effect in
comparison when both are used individually because of their synergistic effects. In this study …
comparison when both are used individually because of their synergistic effects. In this study …
Comparative analysis of point mutations on protein COOH terminal near surface and its hydrophobic core provide insights on thermostability of Bacillus Lipase LipJ
Amino acid composition, protein conformation, weak interactions are some of the factors
determining protein stability. Two point mutants of Bacillus LipJ (Ala81Tyr and Asn166Tyr) …
determining protein stability. Two point mutants of Bacillus LipJ (Ala81Tyr and Asn166Tyr) …
Warm and wet: robust lipase-producing bacteria from the indoor environment
K Tanner, C Abendrotht, M Porcar - bioRxiv, 2017 - biorxiv.org
Lipases are key biocatalysts with important biotechnological applications. With the aim of
isolating robust lipolytic microbial strains, we have analyzed the bacterial communities …
isolating robust lipolytic microbial strains, we have analyzed the bacterial communities …