Important protective roles of intestinal alkaline phosphatase (IAP)–including regulation of
intestinal surface pH, absorption of lipids, detoxification of free nucleotides and bacterial …

Since the 1960s the membrane‐bound enzyme alkaline phosphatase (ALP) has been
utilized in drug delivery. As it cleaves phosphate substructures from drugs, auxiliary agents …

There is a constant need to find feed additives that improve health and nutrition of farmed
fish and lessen the intestinal inflammation induced by plant-based ingredients. The …

Individuals with inflammatory bowel disease are at high risk of developing colitis-associated
cancer; thus, strategies to inhibit disease progression should be investigated. The study …

Evidence supports involvement of microflora in the transition of chronic inflammation to
neoplasia. We investigated the protective efficacy of the probiotic VSL# 3 in a model of colitis …

Rutin, one of the most abundant flavonoids in nature, has been shown to exert intestinal
antiinflammatory effects in experimental models of colitis. Our aim was to study the …

Heterocycles are a class of compounds that have been found to be potent inhibitors of
alkaline phosphatase (AP), an enzyme that plays a critical role in various physiological …

The liver isoform of the enzyme alkaline phosphatase (AP) has been used classically as a
serum biomarker for hepatic disease states such as hepatitis, steatosis, cirrhosis, drug …

The denomination of inflammatory bowel disease comprises a group of chronic inflammatory
diseases of the digestive tract, ulcerative colitis and Crohn's disease being the most …

Herein, we report the first identification of biallelic‐inherited mutations in ALPI as a
Mendelian cause of inflammatory bowel disease in two unrelated patients. ALPI encodes for …