The concept of the neurovascular unit (NVU), formalized at the 2001 Stroke Progress
Review Group meeting of the National Institute of Neurological Disorders and Stroke …

Frontotemporal dementia (FTD) is a highly heritable group of neurodegenerative disorders,
with around 30% of patients having a strong family history. The majority of that heritability is …

The blood coagulation protein fibrinogen is deposited in the brain in a wide range of
neurological diseases and traumatic injuries with blood–brain barrier (BBB) disruption …

Background: Frontotemporal dementia (FTD) describes a cluster of neurocognitive
syndromes that present with impairment of executive functioning, changes in behavior, and …

Background There are few validated fluid biomarkers in frontotemporal dementia (FTD).
Glial fibrillary acidic protein (GFAP) is a measure of astrogliosis, a known pathological …

Connections among brain regions allow pathological perturbations to spread from a single
source region to multiple regions. Patterns of neurodegeneration in multiple diseases …

Summary Background Neurofilament light chain (NfL) is a promising blood biomarker in
genetic frontotemporal dementia, with elevated concentrations in symptomatic carriers of …

Loss-of-function mutations in the progranulin gene (GRN), which encodes progranulin
(PGRN), are a major cause of frontotemporal dementia (FTD). GRN-associated FTD is …

Frontotemporal lobar degeneration (FTLD) represents a group of neurodegenerative brain
diseases with highly heterogeneous clinical, neuropathological and genetic characteristics …

Background Microglial dysfunction is implicated in frontotemporal lobar degeneration
(FTLD). Although studies have reported excessive microglial activation or senescence …