Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: epidemiology, metabolism and the associated diseases

SC Liew, ED Gupta - European journal of medical genetics, 2015 - Elsevier
Abstract The Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is
associated with various diseases (vascular, cancers, neurology, diabetes, psoriasis, etc) …

Clinical implications of the family history in patients with lung cancer: a systematic review of the literature and a new cross-sectional/prospective study design (FAHIC …

F Citarella, K Takada, P Cascetta, P Crucitti… - Journal of Translational …, 2024 - Springer
Compared to other malignancies, few studies have investigated the role of family history of
cancer (FHC) in patients with lung cancer, yielding largely heterogeneous results. We …

Breast cancer risk associated with gene expression and genotype polymorphisms of the folate-metabolizing MTHFR gene: a case-control study in a high altitude …

A López-Cortés, C Echeverría, F Oña-Cisneros… - Tumor Biology, 2015 - Springer
Breast cancer (BC) is the leading cause of cancer-related death among women in 2014.
Methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), and MTR …

Association between MTHFR C677T polymorphism and risk of prostate cancer: Evidence from 22 studies with 10,832 cases and 11,993 controls

M Abedinzadeh, M Zare-Shehneh… - Asian Pacific journal …, 2015 - koreascience.kr
Background: The MTHFR C677T polymorphism is a genetic alteration affecting an enzyme
involved in folate metabolism, but its relationship to host susceptibility to prostate cancer …

Association of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism with primary glaucoma in Saudi population

H Al-Shahrani, N Al-Dabbagh, N Al-Dohayan… - BMC …, 2016 - Springer
Background Methylenetetrahydrofolate reductase (MTHFR), a critical enzyme in folate
metabolism is involved in DNA synthesis, DNA repair and DNA methylation. The functional …

The role of genetic polymorphisms as related to one-carbon metabolism, vitamin B6, and gene–nutrient interactions in maintaining genomic stability and cell viability …

X Wu, W Xu, T Zhou, N Cao, J Ni, T Zou… - International journal of …, 2016 - mdpi.com
Folate-mediated one-carbon metabolism (FMOCM) is linked to DNA synthesis, methylation,
and cell proliferation. Vitamin B6 (B6) is a cofactor, and genetic polymorphisms of related …

[PDF][PDF] MTHFR C677T and A1298C polymorphisms and risk of lung cancer: a comprehensive evaluation

Y Yang, LJ Yang, MZ Deng, YY Luo, S Wu, L Xiong… - Genet Mol …, 2016 - funpecrp.com.br
Results from previous studies on the association between methylenetetrahydrofolate
reductase (MTHFR) polymorphisms C677T and A1298C and lung cancer have been …

[HTML][HTML] Methylenetetrahydrofolate reductase tagging polymorphisms are associated with risk of non-small cell lung cancer in eastern Chinese Han population

H Ding, Y Wang, Y Chen, C Liu, H Qiu, M Kang… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Abstract Previous reports implicated 5, 10-ethylenetetrahydrofolate reductase (MTHFR)
polymorphisms acted as a potential risk factor for several cancers. In order to explore the …

Полиморфные варианты генов фолатного цикла у больных раком легкого

МЛ Баканова, ВИ Минина, ЯА Савченко… - Сибирский …, 2019 - cyberleninka.ru
Рак легкого (РЛ) распространенное онкологическое заболевание и ведущая причина
смертности от рака во всем мире. Особенности метаболизма фолатов в организме …

Association of methylenetetrahydrafolate reductase gene polymorphism (MTHFR) in patients with gallbladder cancer

R Dixit, G Singh, M Pandey, S Basu… - Journal of …, 2016 - Springer
Abstract Purpose 5, 10-Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in
folate metabolism and plays a major role in DNA methylation. There are two popular MTHFR …