Management of infants at risk for group B streptococcal disease

KM Puopolo, R Lynfield, JJ Cummings, I Hand… - …, 2019 - publications.aap.org
Group B streptococcal (GBS) infection remains the most common cause of neonatal early-
onset sepsis and a signiicant cause of late-onset sepsis among young infants …

Prevention of surgical site infection and sepsis in pregnant obese women

E Ekanem, NC Ngene, J Moodley, J Konje - Best Practice & Research …, 2023 - Elsevier
Obesity is a major determinant of health outcomes and is on the increase in women world-
wide. It predisposes to surgical site infection (SSI). Risk factors for the SSI include extremes …

Does the human placenta delivered at term have a microbiota? Results of cultivation, quantitative real-time PCR, 16S rRNA gene sequencing, and metagenomics

KR Theis, R Romero, AD Winters, JM Greenberg… - American journal of …, 2019 - Elsevier
Background The human placenta has been traditionally viewed as sterile, and microbial
invasion of this organ has been associated with adverse pregnancy outcomes. Yet, recent …

Prophylactic cefazolin dosing in obesity—a systematic review

M Coates, A Shield, GM Peterson, Z Hussain - Obesity Surgery, 2022 - Springer
Currently, there is no consensus on whether a standard 2-g prophylactic cefazolin dose
provides sufficient antimicrobial coverage in obese surgical patients. This systematic review …

A systematic review and meta-analysis of wound complications after a caesarean section in obese women

A Słabuszewska-Jóźwiak, JK Szymański… - Journal of clinical …, 2021 - mdpi.com
(1) Background: Caesarean sections in obese patients are associated with an increased risk
of surgical wound complications, including hematomas, seromas, abscesses, dehiscence …

Caesarean section wound infection surveillance: Information for action

SM Scheck, T Blackmore, D Maharaj… - Australian and New …, 2018 - Wiley Online Library
Surgical site infection (SSI) following caesarean section is common, resulting in significant
morbidity. Several factors are known to contribute to wound infection, including maternal …

Maternal obesity and risk of early-onset neonatal bacterial sepsis: nationwide cohort and sibling-controlled studies

E Villamor, M Norman, S Johansson… - Clinical Infectious …, 2021 - academic.oup.com
Background Maternal overweight and obesity are related to risks of pregnancy and delivery
complications that, in turn, are associated with newborn infections. We examined the …

Drugs for the Prevention and Treatment of Sepsis in the Newborn

S Mukhopadhyay, KC Wade… - Clinics in …, 2019 - perinatology.theclinics.com
Antimicrobial medication use is exceedingly common among neonates. Perinatal antibiotic
exposure includes in utero exposure to maternal intrapartum antibiotic prophylaxis (IAP) …

A novel method for quantification of cefazolin local tissue concentration in blood, fat, synovium, and bone marrow using liquid chromatography− mass spectrometry

M Russo, C Monnin, YL Zhang, J Montreuil… - … of Pharmaceutical and …, 2023 - Elsevier
To be effective, the concentration of antibiotic used must exceed the minimum inhibitory
concentration (MIC) against infecting organisms at and in the surgical site. Few studies …

Application of a physiologically based pharmacokinetic model to predict cefazolin and cefuroxime disposition in obese pregnant women undergoing caesarean …

HH Alrammaal, K Abduljalil, V Hodgetts Morton… - Pharmaceutics, 2022 - mdpi.com
Intravenous (IV) cefuroxime and cefazolin are used prophylactically in caesarean sections
(CS). Currently, there are concerns regarding sub-optimal dosing in obese pregnant women …