Animal modelling of traumatic brain injury in preclinical drug development: where do we go from here?

N Marklund, L Hillered - British journal of pharmacology, 2011 - Wiley Online Library
Traumatic brain injury (TBI) is the leading cause of death and disability in young adults.
Survivors of TBI frequently suffer from long‐term personality changes and deficits in …

Animal models of traumatic brain injury

VE Johnson, DF Meaney, DK Cullen… - Handbook of clinical …, 2015 - Elsevier
Traumatic brain injury (TBI) is a major health issue comprising a heterogeneous and
complex array of pathologies. Over the last several decades, numerous animal models have …

[图书][B] Swine in the laboratory: surgery, anesthesia, imaging, and experimental techniques

MM Swindle - 2007 - taylorfrancis.com
To diminish the learning curve associated with using swine as models, Swine in the
Laboratory: Surgery, Anesthesia, Imaging, and Experimental Techniques, Second Edition …

Sex differences in animal models of traumatic brain injury

TG Rubin, ML Lipton - Journal of experimental neuroscience, 2019 - journals.sagepub.com
Traumatic brain injury (TBI) is highly prevalent and there is currently no adequate treatment.
Understanding the underlying mechanisms governing TBI and recovery remains an elusive …

Understanding microglial responses in large animal models of traumatic brain injury: an underutilized resource for preclinical and translational research

MR Grovola, C von Reyn, DJ Loane… - Journal of …, 2023 - Springer
Traumatic brain injury (TBI) often results in prolonged or permanent brain dysfunction with
over 2.8 million affected annually in the US, including over 56,000 deaths, with over 5 million …

The pig as a preclinical traumatic brain injury model: current models, functional outcome measures, and translational detection strategies

HA Kinder, EW Baker, FD West - Neural regeneration research, 2019 - journals.lww.com
Traumatic brain injury (TBI) is a major contributor of long-term disability and a leading cause
of death worldwide. A series of secondary injury cascades can contribute to cell death …

Pre-clinical traumatic brain injury common data elements: toward a common language across laboratories

DH Smith, RR Hicks, VE Johnson… - Journal of …, 2015 - liebertpub.com
Traumatic brain injury (TBI) is a major public health issue exacting a substantial personal
and economic burden globally. With the advent of “big data” approaches to understanding …

Mitochondrial bioenergetic alterations after focal traumatic brain injury in the immature brain

TJ Kilbaugh, M Karlsson, M Byro, A Bebee… - Experimental …, 2015 - Elsevier
Traumatic brain injury (TBI) is one of the leading causes of death in children worldwide.
Emerging evidence suggests that alterations in mitochondrial function are critical …

Backpack-mediated anti-inflammatory macrophage cell therapy for the treatment of traumatic brain injury

N Kapate, R Liao, RL Sodemann, T Stinson… - PNAS …, 2024 - academic.oup.com
Traumatic brain injury (TBI) is a debilitating disease with no current therapies outside of
acute clinical management. While acute, controlled inflammation is important for debris …

Angiopoietin/Tie2 axis regulates the age-at-injury cerebrovascular response to traumatic brain injury

TR Brickler, A Hazy, FG Correa, R Dai… - Journal of …, 2018 - Soc Neuroscience
Although age-at-injury influences chronic recovery from traumatic brain injury (TBI), the
differential effects of age on early outcome remain understudied. Using a male murine …