Type 2 immunity in the skin and lungs

CA Akdis, PD Arkwright, MC Brüggen, W Busse… - Allergy, 2020 - Wiley Online Library
There has been extensive progress in understanding the cellular and molecular
mechanisms of inflammation and immune regulation in allergic diseases of the skin and …

Tissue-specific functions of invariant natural killer T cells

CM Crosby, M Kronenberg - Nature Reviews Immunology, 2018 - nature.com
Invariant natural killer T cells (iNKT cells) are an innate-like T cell subset that expresses an
invariant T cell receptor (TCR) α-chain and recognizes lipids presented on CD1d. They …

[HTML][HTML] Hallmarks of tissue-resident lymphocytes

X Fan, AY Rudensky - Cell, 2016 - cell.com
Although they are classically viewed as continuously recirculating through the lymphoid
organs and blood, lymphocytes also establish residency in non-lymphoid tissues, most …

Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions

PJ Brennan, M Brigl, MB Brenner - Nature Reviews Immunology, 2013 - nature.com
Invariant natural killer T (iNKT) cells exist in a'poised effector'state, which enables them to
rapidly produce cytokines following activation. Using a nearly monospecific T cell receptor …

The role of natural killer T cells in cancer—a phenotypical and functional approach

D Krijgsman, M Hokland, PJK Kuppen - Frontiers in immunology, 2018 - frontiersin.org
Natural killer T (NKT) cells are a subset of CD1d-restricted T cells at the interface between
the innate and adaptive immune system. NKT cells can be subdivided into functional …

The role of the tumor microenvironment and treatment strategies in colorectal cancer

Y Chen, X Zheng, C Wu - Frontiers in immunology, 2021 - frontiersin.org
Colorectal cancer (CRC) has the second highest mortality rate among all cancers
worldwide. Surgery, chemotherapy, radiotherapy, molecular targeting and other treatment …

Recognition of CD1d-restricted antigens by natural killer T cells

J Rossjohn, DG Pellicci, O Patel, L Gapin… - Nature reviews …, 2012 - nature.com
Natural killer T (NKT) cells are innate-like T cells that rapidly produce a variety of cytokines
following T cell receptor (TCR) activation and can shape the immune response in many …

IL-7 licenses activation of human liver intrasinusoidal mucosal-associated invariant T cells

XZ Tang, J Jo, AT Tan, E Sandalova, A Chia… - The Journal of …, 2013 - journals.aai.org
Human mucosal-associated invariant T (MAIT) cells are a T cell population characterized by
the expression of a semi-invariant TCR capable of recognizing bacterial products in the …

CAR-redirected natural killer T cells demonstrate superior antitumor activity to CAR-T cells through multimodal CD1d-dependent mechanisms

X Zhou, Y Wang, Z Dou, G Delfanti, O Tsahouridis… - Nature Cancer, 2024 - nature.com
Human natural killer T (NKT) cells have been proposed as a promising cell platform for
chimeric antigen receptor (CAR) therapy in solid tumors. Here we generated murine CAR …

Initiation of antiviral B cell immunity relies on innate signals from spatially positioned NKT cells

M Gaya, P Barral, M Burbage, S Aggarwal, B Montaner… - Cell, 2018 - cell.com
B cells constitute an essential line of defense from pathogenic infections through the
generation of class-switched antibody-secreting cells (ASCs) in germinal centers. Although …