Milestones in the journey towards addressing obesity; Past trials and triumphs, recent breakthroughs, and an exciting future in the era of emerging effective medical …
The 21st century is characterized by an increasing incidence and prevalence of obesity and
the burden of its associated comorbidities, especially cardiometabolic diseases, which are …
the burden of its associated comorbidities, especially cardiometabolic diseases, which are …
[HTML][HTML] Metabolite profiles of diabetes mellitus and response to intervention in anti-hyperglycemic drugs
Y Liu, D Wang, YP Liu - Frontiers in Endocrinology, 2023 - frontiersin.org
Type 2 diabetes mellitus (T2DM) has become a major health problem, threatening the
quality of life of nearly 500 million patients worldwide. As a typical multifactorial metabolic …
quality of life of nearly 500 million patients worldwide. As a typical multifactorial metabolic …
[HTML][HTML] Semaglutide ameliorates cardiac remodeling in male mice by optimizing energy substrate utilization through the Creb5/NR4a1 axis
YL Ma, CY Kong, Z Guo, MY Wang, P Wang… - Nature …, 2024 - nature.com
Semaglutide, a glucagon-like peptide-1 receptor agonist, is clinically used as a glucose-
lowering and weight loss medication due to its effects on energy metabolism. In heart failure …
lowering and weight loss medication due to its effects on energy metabolism. In heart failure …
[HTML][HTML] Effect of bariatric surgery on cardio-psycho-metabolic outcomes in severe obesity: a randomized controlled trial
AC Koschker, B Warrings, C Morbach, F Seyfried… - Metabolism, 2023 - Elsevier
Objective Randomized evidence comparing the cardiovascular effects of surgical and
conservative weight management is lacking. Patients & methods In this single-center, open …
conservative weight management is lacking. Patients & methods In this single-center, open …
Serum metabolomic profiling reveals potential biomarkers in systemic sclerosis
M Guo, D Liu, Y Jiang, W Chen, L Zhao, D Bao, Y Li… - Metabolism, 2023 - Elsevier
Abstract Background Systemic sclerosis (SSc) is a chronic and systemic autoimmune
disease marked by the skin and visceral fibrosis. Metabolic alterations have been found in …
disease marked by the skin and visceral fibrosis. Metabolic alterations have been found in …
Circulating levels of all proglucagon-derived peptides are differentially regulated postprandially by obesity status and in response to high-fat meals vs. high …
K Stefanakis, A Kokkinos, S Simati, G Argyrakopoulou… - Clinical Nutrition, 2023 - Elsevier
Background & aims We measured all proglucagon-derived peptides (PGDPs) levels in
response to administration of three mixed meal tolerance tests (MMTs), examining …
response to administration of three mixed meal tolerance tests (MMTs), examining …
[HTML][HTML] Changes in Branched-Chain Amino Acids One Year after Sleeve Gastrectomy in Youth with Obesity and Their Association with Changes in Insulin Resistance
Adults with obesity have a reduction in branched-chain amino acid (BCAA) levels following
metabolic and bariatric surgery (MBS), which is hypothesized to contribute to the metabolic …
metabolic and bariatric surgery (MBS), which is hypothesized to contribute to the metabolic …
Circulating levels of proglucagon‐derived peptides are differentially regulated by the glucagon‐like peptide‐1 agonist liraglutide and the centrally acting naltrexone …
K Stefanakis, A Kokkinos… - Diabetes, Obesity …, 2023 - Wiley Online Library
Aim To investigate the changes of circulating levels of all proglucagon‐derived peptides
(PGDPs) in individuals with overweight or obesity receiving liraglutide (3 mg) or …
(PGDPs) in individuals with overweight or obesity receiving liraglutide (3 mg) or …
[HTML][HTML] Short-term metabolic changes and their physiological mediators in the Roux-en-Y gastric bypass bariatric surgery
S Zhao, S Hörkkö, MJ Savolainen, V Koivukangas… - Obesity Surgery, 2024 - Springer
Abstract Background The Roux-en-Y gastric bypass (RYGB) is a common bariatric surgery
to treat obesity. Its metabolic consequences are favourable and long-term clinical corollaries …
to treat obesity. Its metabolic consequences are favourable and long-term clinical corollaries …
Adjuvant and Neo-Adjuvant Anti-Obesity Medications and Bariatric Surgery: A Scoping Review
T Sher, M McGee, C DuCoin, J Sujka… - Current Obesity …, 2024 - Springer
Abstract Purpose of Review To comprehensively summarize the current body of literature on
the topic of adjuvant and neoadjuvant pharmacotherapy used in combination with bariatric …
the topic of adjuvant and neoadjuvant pharmacotherapy used in combination with bariatric …