Multiple roles of chitosan in mucosal drug delivery: an updated review

P Mura, F Maestrelli, M Cirri, N Mennini - Marine Drugs, 2022 - mdpi.com
Chitosan (CS) is a linear polysaccharide obtained by the deacetylation of chitin, which, after
cellulose, is the second biopolymer most abundant in nature, being the primary component …

Stability of chitosan—a challenge for pharmaceutical and biomedical applications

E Szymańska, K Winnicka - Marine drugs, 2015 - mdpi.com
Chitosan—one of the natural multifunctional polymers—due to its unique and versatile
biological properties is regarded as a useful compound in medical and pharmaceutical …

Preparation, characterization and antioxidant activity of protocatechuic acid grafted carboxymethyl chitosan and its hydrogel

C Xu, S Guan, J Xu, W Gong, T Liu, X Ma, C Sun - Carbohydrate Polymers, 2021 - Elsevier
In this study, protocatechuic acid (PCA) was grafted onto carboxymethyl chitosan (CMCS)
via EDC/NHS to improve the antioxidant effect. The grafting ratio of PCA-g-CMCS …

An updated overview of the emerging role of patch and film-based buccal delivery systems

S Jacob, AB Nair, SHS Boddu, B Gorain, N Sreeharsha… - Pharmaceutics, 2021 - mdpi.com
Buccal mucosal membrane offers an attractive drug-delivery route to enhance both systemic
and local therapy. This review discusses the benefits and drawbacks of buccal drug delivery …

Novel and revisited approaches in nanoparticle systems for buccal drug delivery

AS Macedo, PM Castro, L Roque, NG Thomé… - Journal of Controlled …, 2020 - Elsevier
The buccal route is considered patient friendly due to its non-invasive nature and ease of
administration. Such delivery route has been used as an alternative for the delivery of drugs …

Novel mucoadhesive celecoxib-loaded cubosomal sponges: Anticancer potential and regulation of myeloid-derived suppressor cells in oral squamous cell carcinoma

AA Mabrouk, NS El-Mezayen, MI Tadros… - European Journal of …, 2023 - Elsevier
Oral squamous-cell carcinoma (OSCC) is a widespread health problem. Myeloid-derived
suppressor cells (MDSCs) are major tumor microenvironment (TME) population that govern …

Formulation and characterization of fast dissolving oral films containing buspirone hydrochloride nanoparticles using design of experiment

K Bharti, P Mittal, B Mishra - Journal of Drug Delivery Science and …, 2019 - Elsevier
This work aims to prepare fast dissolving oral films (FDOFs) containing nanoparticles of
buspirone hydrochloride (BH). The concept of this formulation provides the drug delivery …

An overview of in vitro dissolution/release methods for novel mucosal drug delivery systems

M Jug, A Hafner, J Lovrić, ML Kregar, I Pepić… - … of pharmaceutical and …, 2018 - Elsevier
In vitro dissolution/release tests are an important tool in the drug product development
phase as well as in its quality control and the regulatory approval process. Mucosal drug …

Highlighting the impact of chitosan on the development of gastroretentive drug delivery systems

MPC de Souza, RM Sábio, T de Cassia Ribeiro… - International Journal of …, 2020 - Elsevier
The development of gastroretentive systems have been growing lately due to the high
demand for carriers that increase drug bioavailability and therapeutic effectiveness after oral …

Chloramphenicol encapsulated in poly-ε-caprolactone–pluronic composite: nanoparticles for treatment of MRSA-infected burn wounds

S Kalita, B Devi, R Kandimalla, KK Sharma… - International journal …, 2015 - Taylor & Francis
The emergence of methicillin-resistant Staphylococcus aureus (MRSA) infection has
increased precipitously over the past several decades, with far-reaching health care and …