Endoplasmic reticulum (ER) chaperones (eg, calreticulin, heat shock proteins, and
isomerases) perform a multitude of functions within the ER. However, many of these …

Background: Molecules secreted by Trypanosoma cruzi (T. cruzi) have beneficial effects on
the immune system and can fight against cancer by inhibiting the growth of tumor cells …

Introduction: Calreticulin is an endoplasmic reticulum (ER) resident protein critical for
maintaining Ca2+ homeostasis and glycoprotein folding in the ER. The protein has also …

American Trypanosomiasis is an important neglected reemerging tropical parasitism,
infecting about 8 million people worldwide. Its agent, Trypanosoma cruzi, exhibits multiple …

Parasites have attained a life-long stigma of being detrimental organisms with deleterious
outcomes. Yet, recently, a creditable twist was verified that can dramatically change our …

Considering the extensive and widespread impact on individuals, cancer can presently be
categorized as a pandemic. In many instances, the development of tumors has been linked …

Calreticulin (CRT) is an endoplasmic reticulum luminal calcium-binding protein with multiple
cellular functions, including intracellular Ca2+ homeostasis, oxidative stress responses, and …

The immune system may aberrantly silence when against “altered self”, which consequently
may develop into malignancies. With the development of tumor immunology and molecular …

Trypanosoma cruzi causes Chagas disease, a neglected disease that can be divided,
overall, into acute and chronic phases. Understanding the mechanisms underlying its …

To successfully infect, Trypanosoma cruzi evades and modulates the host immune
response. T. cruzi calreticulin (TcCalr) is a multifunctional, endoplasmic reticulum (ER) …