Natural killer (NK) cells play a key role in the immune response to certain infections and
malignancies by direct cytolysis of infected or transformed cells and by secretion of potent …

Natural killer (NK) cell education, a process for achieving functional maturation and self-
tolerance, has been previously defined by the interaction between self-major …

From the early days of natural killer (NK) cell research, it was clear that MHC genes
controlled the specificity of mouse NK cell-dependent responses, such as the ability to reject …

Purpose: Immune checkpoint inhibitors have recently revolutionized cancer immunotherapy.
On the basis of data showing KIR-ligand mismatched natural killer (NK) cells reduce the risk …

CD2 is largely described to promote T cell activation when engaged by its ligands, CD48 in
mice and CD58 in humans, that are present on antigen-presenting cells (APCs). However …

T cell receptors (TCRs) recognize peptides presented by MHC molecules (pMHC) on an
antigen-presenting cell (APC) to discriminate foreign from self-antigens and initiate adaptive …

Increased evidence of cross-talk between NK cells and other immune cells has enhanced
the possibilities of exploiting the interplay between the activation and inhibition of NK cells …

The effector potential of NK cells is counterbalanced by their sensitivity to inhibition by" self"
MHC class I molecules in a process called" education." In humans, interactions between …

Natural killer (NK) cells are key components of innate immune responses to tumors and viral
infections. NK cell function is regulated by NK cell receptors that recognize both cellular and …

The NKR-P1 receptors were identified as prototypical natural killer (NK) cell surface
antigens and later shown to be conserved from rodents to humans on NK cells and subsets …