How a fungus shapes biotechnology: 100 years of Aspergillus niger research

TC Cairns, C Nai, V Meyer - Fungal biology and biotechnology, 2018 - Springer
In 1917, a food chemist named James Currie made a promising discovery: any strain of the
filamentous mould Aspergillus niger would produce high concentrations of citric acid when …

Fungal evolution: cellular, genomic and metabolic complexity

MA Naranjo‐Ortiz, T Gabaldón - Biological Reviews, 2020 - Wiley Online Library
The question of how phenotypic and genomic complexity are inter‐related and how they are
shaped through evolution is a central question in biology that historically has been …

Cell biology of hyphal growth

G Steinberg, MA Peñalva, M Riquelme… - Microbiology …, 2017 - Am Soc Microbiol
Filamentous fungi are a large and ancient clade of microorganisms that occupy a broad
range of ecological niches. The success of filamentous fungi is largely due to their elongate …

The mycelium as a network

MD Fricker, LLM Heaton, NS Jones… - The fungal …, 2017 - Wiley Online Library
Growth as an interconnected mycelial network is characteristic of filamentous fungi and has
been subject to scientific investigation since the seminal works of Buller at the start of the …

Fungal growth in batch culture–what we could benefit if we start looking closer

P Vrabl, CW Schinagl, DJ Artmann, B Heiss… - Frontiers in …, 2019 - frontiersin.org
Since filamentous fungi rapidly adjust their metabolic properties to environmental changes,
a rigorous standardization and characterization of cultivation conditions is necessary to …

Large-scale identification of genes involved in septal pore plugging in multicellular fungi

MAA Mamun, W Cao, S Nakamura… - Nature …, 2023 - nature.com
Multicellular filamentous fungi have septal pores that allow cytoplasmic exchange, and thus
connectivity, between neighboring cells in the filament. Hyphal wounding and other stress …

Functional analysis of the Aspergillus fumigatus kinome identifies a druggable DYRK kinase that regulates septal plugging

N van Rhijn, C Zhao, N Al-Furaiji, ISR Storer… - Nature …, 2024 - nature.com
More than 10 million people suffer from lung diseases caused by the pathogenic fungus
Aspergillus fumigatus. Azole antifungals represent first-line therapeutics for most of these …

Cell biology of the Koji mold Aspergillus oryzae

K Kitamoto - Bioscience, biotechnology, and biochemistry, 2015 - academic.oup.com
Koji mold, Aspergillus oryzae, has been used for the production of sake, miso, and soy
sauce for more than one thousand years in Japan. Due to the importance, A. oryzae has …

Syncytia in fungi

AP Mela, AM Rico-Ramírez, NL Glass - Cells, 2020 - mdpi.com
Filamentous fungi typically grow as interconnected multinucleate syncytia that can be
microscopic to many hectares in size. Mechanistic details and rules that govern the …

Understanding microbial divisions of labor

Z Zhang, D Claessen, DE Rozen - Frontiers in microbiology, 2016 - frontiersin.org
Divisions of labor are ubiquitous in nature and can be found at nearly every level of
biological organization, from the individuals of a shared society to the cells of a single …