Self-grooming is a complex innate behaviour with an evolutionarily conserved sequencing
pattern and is one of the most frequently performed behavioural activities in rodents. In this …

Dopamine (DA) transmission is governed by processes that regulate release from axonal
boutons in the forebrain and the somatodendritic compartment in midbrain, and by …

The function of the mammalian brain relies upon the specification and spatial positioning of
diversely specialized cell types. Yet, the molecular identities of the cell types and their …

Recent progress in understanding the diversity of midbrain dopamine neurons has
highlighted the importance—and the challenges—of defining mammalian neuronal cell …

The striatum contributes to many cognitive processes and disorders, but its cell types are
incompletely characterized. We show that microfluidic and FACS-based single-cell RNA …

Corticostriatal projections are essential components of forebrain circuits and are widely
involved in motivated behaviour. These axonal projections are formed by two distinct …

This Perspective will examine the organization of intrastriatal circuitry, review recent findings
in this area, and discuss how the pattern of connectivity between striatal neurons might give …

In light of the clinical evidence implicating dopamine in schizophrenia and the prominent
hypotheses put forth regarding alterations in dopaminergic transmission in this disease …

Dysfunctions in frontostriatal brain circuits have been implicated in neuropsychiatric
disorders, including those characterized by the presence of repetitive behaviors. We …

Different striatal projection neurons are the origin of a dual organization essential for basal
ganglia function. We have defined an analogous division of labor in the external globus …