Alzheimer's disease (AD) is heterogenous at the molecular level. Understanding this
heterogeneity is critical for AD drug development. Here we define AD molecular subtypes …

The Netherlands Twin Register (NTR) is a national register in which twins, multiples and
their parents, siblings, spouses and other family members participate. Here we describe the …

Objective To investigate the relationship between the ATN classification system (amyloid,
tau, neurodegeneration) and risk of dementia and cognitive decline in individuals with …

Background Amyloid-β (Aβ) accumulation is considered the earliest pathological change in
Alzheimer's disease (AD). The Amyloid Imaging to Prevent Alzheimer's Disease (AMYPAD) …

Background and Objectives β-amyloid (Aβ) staging models assume a single spatial-
temporal progression of amyloid accumulation. We assessed evidence for Aβ accumulation …

Background/aims As a protrusion from the brain, the retina might reflect the status of the
brain. Previous studies showed a decrease in vessel density and foveal avascular zone …

Objective To develop and evaluate a model for staging cortical amyloid deposition using
PET with high generalizability. Methods Three thousand twenty-seven individuals (1,763 …

Purpose There is urgent need for non‐invasive diagnostic biomarkers in the preclinical
phase of Alzheimer's Disease (AD). Several studies suggest that retinal thickness is reduced …

Introduction Amyloid beta (Aβ) accumulation is the first pathological hallmark of Alzheimer's
disease (AD), and it is associated with altered white matter (WM) microstructure. We aimed …

Tau accumulation starts during the preclinical phase of Alzheimer's disease and is closely
associated with cognitive decline. For preventive purposes, it is important to identify factors …