Biotin, a universal and essential cofactor: synthesis, ligation and regulation
C Sirithanakorn, JE Cronan - FEMS Microbiology Reviews, 2021 - academic.oup.com
Biotin is a covalently attached enzyme cofactor required for intermediary metabolism in all
three domains of life. Several important human pathogens (eg Mycobacterium tuberculosis) …
three domains of life. Several important human pathogens (eg Mycobacterium tuberculosis) …
Solar-driven green synthesis of epoxides
D Tang, K Dang, J Wang, C Chen, J Zhao… - Science China …, 2023 - Springer
Epoxides are one of the most important intermediates used in the production of valuable
chemicals. Traditional preparation methods often rely on hazardous oxidants or extensive …
chemicals. Traditional preparation methods often rely on hazardous oxidants or extensive …
Recognition of surface oxygen intermediates on NiFe oxyhydroxide oxygen-evolving catalysts by homogeneous oxidation reactivity
NiFe oxyhydroxide is one of the most promising oxygen evolution reaction (OER) catalysts
for renewable hydrogen production, and deciphering the identity and reactivity of the oxygen …
for renewable hydrogen production, and deciphering the identity and reactivity of the oxygen …
Nature's machinery, repurposed: expanding the repertoire of iron-dependent oxygenases
Iron is an especially important redox-active cofactor in biology because of its ability to
mediate reactions with atmospheric O2. Iron-dependent oxygenases exploit this earth …
mediate reactions with atmospheric O2. Iron-dependent oxygenases exploit this earth …
Enzymatic catalysis favours eight-membered over five-membered ring closure in bicyclomycin biosynthesis
JB He, L Wu, W Wei, S Meng, ZT Liu, X Wu, HX Pan… - Nature Catalysis, 2023 - nature.com
The construction of O-heterocycles is an important step in organic synthesis and
biosynthesis for producing valuable ring compounds. Although enzyme-catalysed five-or six …
biosynthesis for producing valuable ring compounds. Although enzyme-catalysed five-or six …
Highly selective synthesis of surface FeIV=O with nanoscale zero-valent iron and chlorite for efficient oxygen transfer reactions
High-valent iron-oxo species (FeIV= O) has been a long-sought-after oxygen transfer
reagent in biological and catalytic chemistry but suffers from a giant challenge in its gentle …
reagent in biological and catalytic chemistry but suffers from a giant challenge in its gentle …
Structure-driven protein engineering for production of valuable natural products
Y Wang, L Yu, J Shao, Z Zhu, L Zhang - Trends in Plant Science, 2023 - cell.com
Proteins are the most frequently used biocatalysts, and their structures determine their
functions. Modifying the functions of proteins on the basis of their structures lies at the heart …
functions. Modifying the functions of proteins on the basis of their structures lies at the heart …
Engineering the Reaction Pathway of a Non-heme Iron Oxygenase Using Ancestral Sequence Reconstruction
Non-heme iron (FeII), α-ketoglutarate (α-KG)-dependent oxygenases are a family of
enzymes that catalyze an array of transformations that cascade forward after the formation of …
enzymes that catalyze an array of transformations that cascade forward after the formation of …
Optimized Substrate Positioning Enables Switches in the C–H Cleavage Site and Reaction Outcome in the Hydroxylation–Epoxidation Sequence Catalyzed by …
ES Wenger, RJ Martinie, R Ushimaru… - Journal of the …, 2024 - ACS Publications
Hyoscyamine 6β-hydroxylase (H6H) is an iron (II)-and 2-oxoglutarate-dependent (Fe/2OG)
oxygenase that produces the prolifically administered antinausea drug, scopolamine. After …
oxygenase that produces the prolifically administered antinausea drug, scopolamine. After …
Structural insight into the catalytic mechanism of the endoperoxide synthase FtmOx1
Abstract The 2‐oxoglutarate (2OG)‐dependent non‐heme enzyme FtmOx1 catalyzes the
endoperoxide biosynthesis of verruculogen. Although several mechanistic studies have …
endoperoxide biosynthesis of verruculogen. Although several mechanistic studies have …