Despite decades of research, brain tumours remain among the deadliest of all forms of
cancer. The ability of these tumours to resist almost all conventional and novel treatments …

Breast cancer (BC) is the most common cancer in women and poses a serious threat to their
health. Despite familiarity with factors affecting its etiology, initiation, progression, treatment …

Multiple independent genomic profiling efforts have recently identified clinically and
molecularly distinct subgroups of ependymoma arising from all three anatomic …

Ependymoma is a heterogeneous entity of central nervous system tumors with well-
established molecular groups. Here, we apply single-cell RNA sequencing to analyze …

The childhood brain tumor, medulloblastoma, includes four subtypes with very different
prognoses. Here, we show that paracrine signals driven by mutant β-catenin in WNT …

Genomic sequencing has driven precision-based oncology therapy; however, the genetic
drivers of many malignancies remain unknown or non-targetable, so alternative approaches …

Ependymomas are rare central nervous system tumours that can arise in the brain's
supratentorial region or posterior fossa, or in the spinal cord. In 1924, Percival Bailey …

Chromosome 17q gains are almost invariably present in high-risk neuroblastoma cases.
Here, we perform an integrative epigenomics search for dosage-sensitive transcription …

Abstract ZFTA (C11orf95)—a gene of unknown function—partners with a variety of
transcriptional coactivators in translocations that drive supratentorial ependymoma, a …

Simple Summary Brain tumors remain the most common childhood solid tumors, accounting
for approximately 25% of all pediatric cancers. They also represent the most common cause …