Metastasis is responsible for 90% of deaths in patients with cancer. Understanding the role
of metabolism during metastasis has been limited by the development of robust and …

Gluconeogenesis is a critical biosynthetic process that helps maintain whole-body glucose
homeostasis and becomes altered in certain medical diseases. We review gluconeogenic …

How phosphate levels are detected in mammals is unknown. The bone-derived hormone
fibroblast growth factor 23 (FGF23) lowers blood phosphate levels by reducing kidney …

Adiponectin is a secretory protein, primarily produced in adipocytes. However, low but
detectable expression of adiponectin can be observed in cell types beyond adipocytes …

Metabolic flux analysis (MFA) combines experimental measurements and computational
modeling to determine biochemical reaction rates in live biological systems. Advancements …

Mitochondrial hydroxymethylglutaryl-CoA synthase 2 (HMGCS2) is the rate-limiting enzyme
in ketogenesis. The liver expresses high levels of HMGCS2 constitutively as the main …

Isotope-assisted metabolic flux analysis (iMFA) is a powerful method to mathematically
determine the metabolic fluxome from experimental isotope labeling data and a metabolic …

Glucose tolerance represents a complex phenotype in which many tissues play important
roles and interact to regulate metabolic homeostasis. Here, we perform an analysis of 13 C 6 …

Background Existing research has suggested that depression results in disorders of glucose
metabolism in the organism which causing insufficient energy supply. However, the overall …

In commemoration of 100 years since the discovery of glucagon, we review current
knowledge about the human α cell. Alpha cells make up 30–40% of human islet endocrine …