During decades, the research field of cancer metabolism was based on the Warburg effect,
described almost one century ago. Lately, the key role of mitochondria in cancer …

The resurgence of research into cancer metabolism has recently broadened interests
beyond glucose and the Warburg effect to other nutrients, including glutamine. Because …

IDH1 mutations are common in low-grade gliomas and secondary glioblastomas and cause
overproduction of (R)-2HG.(R)-2HG modulates the activity of many enzymes, including some …

Glutamine serves as an important source of energy and building blocks for many tumor cells.
The first step in glutamine utilization is its conversion to glutamate by the mitochondrial …

Cancer cells have metabolic dependencies that distinguish them from their normal
counterparts. Among these dependencies is an increased use of the amino acid glutamine …

Glutaminase (GLS), which converts glutamine to glutamate, plays a key role in cancer cell
metabolism, growth, and proliferation. GLS is being explored as a cancer therapeutic target …

Because MYC plays a causal role in many human cancers, including those with hypoxic and
nutrient-poor tumor microenvironments, we have determined the metabolic responses of a …

Metabolism generates oxygen radicals, which contribute to oncogenic mutations. Activated
oncogenes and loss of tumor suppressors in turn alter metabolism and induce aerobic …

Cancer cells are well documented to rewire their metabolism and energy production
networks to support and enable rapid proliferation, continuous growth, survival in harsh …

Calorie restriction (CR) extends life span in diverse species. Mitochondria play a key role in
CR adaptation; however, the molecular details remain elusive. We developed and applied a …