[HTML][HTML] The different autophagy degradation pathways and neurodegeneration
The term autophagy encompasses different pathways that route cytoplasmic material to
lysosomes for degradation and includes macroautophagy, chaperone-mediated autophagy …
lysosomes for degradation and includes macroautophagy, chaperone-mediated autophagy …
Macroautophagy in CNS health and disease
CJ Griffey, A Yamamoto - Nature Reviews Neuroscience, 2022 - nature.com
Macroautophagy is an evolutionarily conserved process that delivers diverse cellular
contents to lysosomes for degradation. As our understanding of this pathway grows, so does …
contents to lysosomes for degradation. As our understanding of this pathway grows, so does …
Brain-derived autophagosome profiling reveals the engulfment of nucleoid-enriched mitochondrial fragments by basal autophagy in neurons
Neurons depend on autophagy to maintain cellular homeostasis, and defects in autophagy
are pathological hallmarks of neurodegenerative disease. To probe the role of basal …
are pathological hallmarks of neurodegenerative disease. To probe the role of basal …
Asperosaponin VI ameliorates the CMS-induced depressive-like behaviors by inducing a neuroprotective microglial phenotype in hippocampus via PPAR-γ pathway
X Jiang, S Yi, Q Liu, D Su, L Li, C Xiao… - Journal of …, 2022 - Springer
Background The natural compound asperosaponin VI has shown potential as an
antidepressant, but how it works is unclear. Here, we explored its effects on mice exposed to …
antidepressant, but how it works is unclear. Here, we explored its effects on mice exposed to …
Dendritic autophagy degrades postsynaptic proteins and is required for long-term synaptic depression in mice
E Kallergi, AD Daskalaki, A Kolaxi, C Camus… - Nature …, 2022 - nature.com
The pruning of dendritic spines during development requires autophagy. This process is
facilitated by long-term depression (LTD)-like mechanisms, which has led to speculation that …
facilitated by long-term depression (LTD)-like mechanisms, which has led to speculation that …
Quantifying postsynaptic receptor dynamics: insights into synaptic function
The molecular composition of presynaptic and postsynaptic neuronal terminals is dynamic,
and yet long-term stabilizations in postsynaptic responses are necessary for synaptic …
and yet long-term stabilizations in postsynaptic responses are necessary for synaptic …
ATP-mediated signalling in the central synapses
U Lalo, Y Pankratov - Neuropharmacology, 2023 - Elsevier
ATP released from the synaptic terminals and astrocytes can activate neuronal P2 receptors
at a variety of locations across the CNS. Although the postsynaptic ATP-mediated signalling …
at a variety of locations across the CNS. Although the postsynaptic ATP-mediated signalling …
Deep proteomics identifies shared molecular pathway alterations in synapses of patients with schizophrenia and bipolar disorder and mouse model
Synaptic dysfunction is implicated in the pathophysiology of schizophrenia (SCZ) and
bipolar disorder (BP). We use quantitative mass spectrometry to carry out deep, unbiased …
bipolar disorder (BP). We use quantitative mass spectrometry to carry out deep, unbiased …
A PSD-95 peptidomimetic mitigates neurological deficits in a mouse model of Angelman syndrome
KA Lau, X Yang, MS Rioult-Pedotti, S Tang… - Progress in …, 2023 - Elsevier
Angelman Syndrome (AS) is a severe cognitive disorder caused by loss of neuronal
expression of the E3 ubiquitin ligase UBE3A. In an AS mouse model, we previously reported …
expression of the E3 ubiquitin ligase UBE3A. In an AS mouse model, we previously reported …
Autophagy regulates neuronal excitability by controlling cAMP/protein kinase A signaling at the synapse
M Overhoff, F Tellkamp, S Hess, M Tolve, J Tutas… - The EMBO …, 2022 - embopress.org
Autophagy provides nutrients during starvation and eliminates detrimental cellular
components. However, accumulating evidence indicates that autophagy is not merely a …
components. However, accumulating evidence indicates that autophagy is not merely a …