Biogenesis and regulation of the let-7 miRNAs and their functional implications
H Lee, S Han, CS Kwon, D Lee - Protein & cell, 2016 - academic.oup.com
The let-7 miRNA was one of the first miRNAs discovered in the nematode, Caenorhabditis
elegans, and its biological functions show a high level of evolutionary conservation from the …
elegans, and its biological functions show a high level of evolutionary conservation from the …
The let-7 family of microRNAs
S Roush, FJ Slack - Trends in cell biology, 2008 - cell.com
The first two known microRNAs (miRNAs), lin-4 and let-7, were originally discovered in the
nematode Caenorhabditis elegans and control the timing of stem-cell division and …
nematode Caenorhabditis elegans and control the timing of stem-cell division and …
Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation
Abstract Background The microRNAs (miRNAs) are an extensive class of small noncoding
RNAs (18 to 25 nucleotides) with probable roles in the regulation of gene expression. In …
RNAs (18 to 25 nucleotides) with probable roles in the regulation of gene expression. In …
Target RNA–directed trimming and tailing of small silencing RNAs
In Drosophila, microRNAs (miRNAs) typically guide Argonaute1 to repress messenger RNA
(mRNA), whereas small interfering RNAs (siRNAs) guide Argonaute2 to destroy viral and …
(mRNA), whereas small interfering RNAs (siRNAs) guide Argonaute2 to destroy viral and …
The role of let-7 in cell differentiation and cancer
B Boyerinas, SM Park, A Hau… - Endocrine-related …, 2010 - erc.bioscientifica.com
MicroRNAs (miRNAs or miRs) are small noncoding RNAs capable of regulating gene
expression at the translational level. Current evidence suggests that a significant portion of …
expression at the translational level. Current evidence suggests that a significant portion of …
Temporal Patterning in the Drosophila CNS
CQ Doe - Annual review of cell and developmental biology, 2017 - annualreviews.org
A small pool of neural progenitors generates the vast diversity of cell types in the CNS.
Spatial patterning specifies progenitor identity, followed by temporal patterning within …
Spatial patterning specifies progenitor identity, followed by temporal patterning within …
Involvement of microRNA in AU-rich element-mediated mRNA instability
Q Jing, S Huang, S Guth, T Zarubin, A Motoyama… - Cell, 2005 - cell.com
AU-rich elements (AREs) in the 3′ untranslated region (UTR) of unstable mRNAs dictate
their degradation. An RNAi-based screen performed in Drosophila S2 cells has revealed …
their degradation. An RNAi-based screen performed in Drosophila S2 cells has revealed …
Computational identification of DrosophilamicroRNA genes
Background MicroRNAs (miRNAs) are a large family of 21-22 nucleotide non-coding RNAs
with presumed post-transcriptional regulatory activity. Most miRNAs were identified by direct …
with presumed post-transcriptional regulatory activity. Most miRNAs were identified by direct …
The micro-ribonucleic acid (miRNA) miR-206 targets the human estrogen receptor-α (ERα) and represses ERα messenger RNA and protein expression in breast …
Micro-RNAs are small noncoding RNAs, which diminish the stability and/or translation of
mRNAs. This study examined whether miR-206, previously shown to be elevated in …
mRNAs. This study examined whether miR-206, previously shown to be elevated in …
MicroRNA functions in insects
S Asgari - Insect biochemistry and molecular biology, 2013 - Elsevier
MicroRNAs (miRNAs) are small non-coding RNAs that are generated in all eukaryotes and
viruses. Their role as master regulators of gene expression in various biological processes …
viruses. Their role as master regulators of gene expression in various biological processes …