Spermatogonial stem cells (SSCs) are the only adult stem cells capable of passing genes
onto the next generation. SSCs also have the potential to provide important knowledge …

Aim To provide practice guidelines about fertility preservation (FP) in oncology. Methods We
selected 400 articles after a PubMed review of the literature (1987–2019) …

In recent years, there has been an increased incidence in several of the most common
reproductive disorders, including hypospadias and cryptorchidism in newborns, and …

Engineered male and female biomimetic reproductive tissues are being developed as
autonomous in vitro units or as integrated multi-organ in vitro systems to support germ cell …

BACKGROUND Childhood cancer incidence and survivorship are both on the rise.
However, many lifesaving treatments threaten the prepubertal testis. Cryopreservation of …

Medical treatments for cancers or other conditions can lead to permanent infertility. Infertility
is an insidious disease that impacts not only the ability to have a biological child but also the …

While in mice various studies have described the completion of spermatogenesis in vitro
using either organotypic culture of prepubertal testicular tissue or 3D culture of isolated cells …

BACKGROUND In recent decades, a broad range of strategies have been applied to model
the testicular microenvironment in vitro. These models have been utilized to study testicular …

Introduction 3D printing, a versatile additive manufacturing technique, has diverse
applications ranging from transportation, rapid prototyping, clean energy, and medical …

In vitro spermatogenesis (IVS) has already been successfully achieved in rodents by
organotypic and soft matrix culture systems. However, the former does not allow single cell …