Results from recent clinical trials of antibodies that target amyloid-β (Aβ) for Alzheimer's
disease have created excitement and have been heralded as corroboration of the amyloid …

Alzheimer's disease (AD) is marked by the presence of extracellular amyloid beta (Aβ)
plaques, intracellular neurofibrillary tangles (NFTs) and gliosis, activated glial cells, in the …

A hallmark of Alzheimer's disease (AD) is the aggregation of β-amyloid peptides (Aβ) into
amyloid plaques in patient brain. Cleavage of amyloid precursor protein (APP) by the …

Mutations in the PSEN1 gene, encoding presenilin-1 (PS1), are the most common cause of
familial Alzheimer's disease (FAD). PS1 functions as the catalytic subunit of γ-secretase, an …

Presenilin-1 (PSEN1) has been verified as an important causative factor for early onset
Alzheimer's disease (EOAD). PSEN1 is a part of γ-secretase, and in addition to amyloid …

Alzheimer's disease (AD) is the disease of lost memories. Synaptic loss is a major reason for
memory defects in AD. Signaling pathways involved in memory loss in AD are under intense …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that accounts for the
most cases of dementia, which is characterized by the deposition of dense plaques of …

Mutations in presenilin 1 and 2 (PS1 and PS2) cause autosomal dominant familial
Alzheimer's disease (FAD). Ferroptosis has been implicated as a mechanism of …

The elimination of abnormal and dysfunctional cellular constituents is an essential
prerequisite for nerve cells to maintain their homeostasis and proper function. This is mainly …

Recently it was proposed that the familial Alzheimer's disease (FAD) causing presenilin
(PSEN) mutations PSEN1-L435F and PSEN1-C410Y do not support the generation of Aβ …