Copper, an essential trace element that exists in oxidized and reduced forms, has pivotal
roles in a variety of biological processes, including redox chemistry, enzymatic reactions …

Copper homeostasis is tightly regulated in both prokaryotic and eukaryotic cells to ensure
sufficient amounts for cuproprotein biosynthesis, while limiting oxidative stress production …

Copper is well known for its antimicrobial and antiviral properties. Under aerobic conditions,
copper toxicity relies in part on the production of reactive oxygen species (ROS), especially …

The pathophysiology of ALS involves many signs of a disruption in copper homeostasis, with
both excess free levels and functional deficiency likely occurring simultaneously. This is …

Characterizing mechanisms of protein homeostasis, a process of balancing between protein
synthesis and protein degradation, is important for understanding the potential causes of …

Copper (Cu), a crucial trace element in physiological processes, has garnered significant
interest for its involvement in cancer progression and potential therapeutic applications. The …

Legionella pneumophila translocates the largest known arsenal of over 330 pathogenic
factors, called" effectors," into host cells during infection, enabling L. pneumophila to …

Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) is a potent toxin used to selectively
destroy dopaminergic neurons in the substantia nigra and induce parkinsonism. MPTP is …

Gene multiplications or point mutations in alpha (α)-synuclein are associated with familial
and sporadic Parkinson's disease (PD). An increase in copper (Cu) levels has been …

Copper (Cu) is an essential micronutrient for cells, but in excess it is cytotoxic. How Cu is
cytotoxic is the subject of recent work by L. Zuily, N. Lahrach, R. Fassler, O. Genest, et …