FtsZ, a bacterial homolog of tubulin, is well established as forming the cytoskeletal
framework for the cytokinetic ring. Recent work has shown that purified FtsZ, in the absence …

This review covers some of the opportunities which currently exist to exploit plants for their
natural products as templates for new antibacterial substances. This is a timely exercise …

Complete synthetic, structural, and biomedical studies of two Pd complexes as well as Au
and Ag complexes of 1-benzyl-3-tert-butylimidazol-2-ylidene are reported. Specifically, trans …

The assembly and stability of FtsZ protofilaments have been shown to play critical roles in
bacterial cytokinesis. Recent evidence suggests that FtsZ may be considered as an …

Background Berberine is a plant alkaloid that is widely used as an anti-infective in traditional
medicine. Escherichia coli exposed to berberine form filaments, suggesting an antibacterial …

The ever increasing problem of antibiotic resistance necessitates a search for new drug
molecules that would target novel proteins in the prokaryotic system. FtsZ is one such target …

The continuous emergence and rapid spread of a multidrug-resistant strain of bacterial
pathogens have demanded the discovery and development of new antibacterial agents. A …

Libraries of novel trisubstituted benzimidazoles were created through rational drug design. A
good number of these benzimidazoles exhibited promising MIC values in the range of 0.5− 6 …

Similar to its eukaryotic counterpart, the prokaryotic cytoskeleton is essential for the
structural and mechanical properties of bacterial cells. The essential protein FtsZ is a central …

The disturbing increase in the number of bacterial pathogens that are resistant to multiple, or
sometimes all, current antibiotics highlights the desperate need to pursue the discovery and …