Double-stranded RNA-mediated interference (RNAi) is a simple and rapid method of
silencing gene expression in a range of organisms. The silencing of a gene is a …

Among the 3 billion base pairs of the human genome, there are∼ 30,000–40,000 protein-
coding genes, but the function of at least half of them remains unknown. A new tool—short …

Small interfering RNAs (siRNAs) are the mediators of mRNA degradation in the process of
RNA interference (RNAi). Here, we describe a human biochemical system that recapitulates …

Short interfering RNA (siRNA) is used in RNA interference technology to avoid non-target-
related induction of type I interferon (IFN) typical for long double-stranded RNA. Here we …

Diverse eukaryotic hosts produce virus-derived small interfering RNAs (siRNAs) to direct
antiviral immunity by RNA interference (RNAi). However, it remains unknown whether the …

Short interfering RNAs can be used to silence gene expression in a sequence-specific
manner in a process that is known as RNA interference. The application of RNA interference …

Molecules that can specifically silence gene expression are powerful research tools. Much
effort has been put into the development of such molecules and has resulted in the creation …

RNA interference (RNAi) is a highly conserved gene silencing mechanism that uses double-
stranded RNA (dsRNA) as a signal to trigger the degradation of homologous mRNA. The …

RNA interference is an evolutionarily conserved surveillance mechanism that responds to
double-stranded RNA by sequence-specific silencing of homologous genes. Here we show …

Chronic hepatitis B (CHB) is a major cause of liver-related morbidity and mortality.
Functional cure of CHB, defined as sustainable hepatitis B surface antigen (HBsAg) …