Brain washing and neural health: role of age, sleep, and the cerebrospinal fluid melatonin rhythm
The brain lacks a classic lymphatic drainage system. How it is cleansed of damaged
proteins, cellular debris, and molecular by-products has remained a mystery for decades …
proteins, cellular debris, and molecular by-products has remained a mystery for decades …
Bridging neurotrophic factors and bioactive peptides to Alzheimer's disease
M Wei, T Wu, N Chen - Ageing Research Reviews, 2024 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder. As the demographic shifting
towards an aging population, AD has emerged as a prominent public health concern. The …
towards an aging population, AD has emerged as a prominent public health concern. The …
Mechanistic insight into the disruption of Tau R3–R4 protofibrils by curcumin and epinephrine: An all-atom molecular dynamics study
The accumulation of Tau protein aggregates is a pathological hallmark of tauopathy,
including chronic traumatic encephalopathy (CTE). Inhibiting Tau aggregation or disrupting …
including chronic traumatic encephalopathy (CTE). Inhibiting Tau aggregation or disrupting …
Phosphorylation of Tau R2 Repeat Destabilizes Its Binding to Microtubules: A Molecular Dynamics Simulation Study
Phosphorylation, the most popular post-translational modification of tau protein, plays an
important role in regulating tau physiological functions. However, aberrant phosphorylation …
important role in regulating tau physiological functions. However, aberrant phosphorylation …
Light, water, and melatonin: the synergistic regulation of phase separation in dementia
The swift rise in acceptance of molecular principles defining phase separation by a broad
array of scientific disciplines is shadowed by increasing discoveries linking phase …
array of scientific disciplines is shadowed by increasing discoveries linking phase …
Mechanistic insights into the binding of different positron emission tomography tracers to chronic traumatic encephalopathy tau protofibrils
B Qi, J Tan, Y Sun, M Cao, J Lin… - ACS Chemical …, 2023 - ACS Publications
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with
exposure to repetitive head impacts, and it is neuropathologically defined as the …
exposure to repetitive head impacts, and it is neuropathologically defined as the …
Melatonin inhibits hIAPP oligomerization by preventing β-sheet and hydrogen bond formation of the amyloidogenic region revealed by replica-exchange molecular …
The pathogenesis of type 2 diabetes (T2D) is highly related to the abnormal self-assembly of
the human islet amyloid polypeptide (hIAPP) into amyloid aggregates. To inhibit hIAPP …
the human islet amyloid polypeptide (hIAPP) into amyloid aggregates. To inhibit hIAPP …
A brief history of amyloid aggregation simulations
Amyloid proteins are characterized by their tendency to aggregate into amyloid fibrils, which
are often associated with devastating diseases. Aggregation pathways typically involve …
are often associated with devastating diseases. Aggregation pathways typically involve …
Neuroprotective Effect of Combined Treatment with Epigallocatechin 3-Gallate and Melatonin on Familial Alzheimer's Disease PSEN1 E280A Cerebral Spheroids …
V Soto-Mercado, M Mendivil-Perez… - Journal of …, 2024 - journals.sagepub.com
Background: Familial Alzheimer's disease (FAD) is caused by mutations in one or more of 3
genes known as AβPP, PSEN1, and PSEN2. There are currently no effective therapies for …
genes known as AβPP, PSEN1, and PSEN2. There are currently no effective therapies for …
Effects of Charged Polyelectrolytes on Amyloid Fibril Formation of a Tau Fragment
The microtubule-associated protein tau is involved in more than 20 different neurological
disorders characterized by aberrant intracellular aggregation of tau in the brain. Here, we …
disorders characterized by aberrant intracellular aggregation of tau in the brain. Here, we …