Found throughout biology, polyvalent interactions are characterized by the simultaneous
binding of multiple ligands on one biological entity to multiple receptors on another (top part …

▪ Abstract Hemagglutinin (HA) is the receptor-binding and membrane fusion glycoprotein of
influenza virus and the target for infectivity-neutralizing antibodies. The structures of three …

Cell‐surface receptors acquire information from the extracellular environment and
coordinate intracellular responses. Many receptors do not operate as individual entities, but …

Influenza hemagglutinin(HA) undergoes a conformational change that Induces viral fusion
with the cellular membrane. The structure of HA in the fusogenic state is unknown. We have …

A quantitative model is proposed for the analysis of the thermodynamic parameters of
multivalent interactions in dilute solutions or with immobilized multimeric receptor. The …

The development of small molecules that target RNA is challenging yet, if successful, could
advance the development of chemical probes to study RNA function or precision …

We report a strategy (called “tethering”) to discover low molecular weight ligands (≈ 250
Da) that bind weakly to targeted sites on proteins through an intermediary disulfide tether. A …

The binding of simple carbohydrate ligands by proteins often requires affinity enhancement
to attain biologically relevant strength. This is especially true for endocytotic receptors and …

Sialic acids (Sias) are terminal components of many glycoproteins and glycolipids especially
of higher animals. In this exposed position they contribute significantly to the structural …

Multivalency is a powerful and versatile self-assembly pathway that confers unique
thermodynamic and kinetic behavior onto supramolecular complexes. The diversity of the …