The impaired response inhibition and salience attribution (iRISA) model proposes that
impaired response inhibition and salience attribution underlie drug seeking and taking. To …

The central amygdala (CeA) plays a central role in physiologic and behavioral responses to
fearful stimuli, stressful stimuli, and drug-related stimuli. The CeA receives dense inputs from …

Human neuroimaging studies suggest that neural cue reactivity is strongly associated with
indices of drug use, including addiction severity and treatment success. However, little is …

Altered brain responses to alcohol-associated stimuli are a neural hallmark of alcohol-use
disorder (AUD) and a promising target for pharmacotherapy. However, findings in cue …

Similarities and differences between obesity and addiction are a prominent topic of ongoing
research. We conducted an activation likelihood estimation meta‐analysis on 87 studies in …

Recent findings in a range of scientific disciplines are challenging the conventional wisdom
regarding the etiology, classification, and treatment of psychiatric disorders. This Review …

The incentive salience sensitization (ISS) theory of addiction holds that addictive behavior
stems from the ability of drugs to progressively sensitize the brain circuitry that mediates …

Time‐dependent increases in cue‐induced nicotine and methamphetamine craving during
abstinence were recently reported in human drug‐dependent individuals. In the present …

Proprioceptive sensory signals inform the CNS of the consequences of motor acts, but
effective motor planning involves internal neural systems capable of anticipating actual …

Alterations in appetitive processing are central to the major psychological theories of
addiction, with differential predictions made by the reward deficiency, incentive salience …