Crosstalk between PD-1/PD-L1 blockade and its combinatorial therapies in tumor immune microenvironment: a focus on HNSCC
W Lin, M Chen, L Hong, H Zhao, Q Chen - Frontiers in oncology, 2018 - frontiersin.org
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy
worldwide with a poor prognosis and high mortality. More than two-thirds of HNSCC patients …
worldwide with a poor prognosis and high mortality. More than two-thirds of HNSCC patients …
The prognostic and therapeutic value of the mutational profile of blood and tumor tissue in head and neck squamous cell carcinoma
HL Wilson, RB D'Agostino Jr, N Meegalla… - The …, 2021 - academic.oup.com
Background The purpose of this study was to explore the genomic landscape of head and
neck squamous cell carcinoma (HNSCC) in circulation (circulating tumor DNA [ctDNA]) and …
neck squamous cell carcinoma (HNSCC) in circulation (circulating tumor DNA [ctDNA]) and …
[HTML][HTML] Window of opportunity trials in head and neck cancer
Head and neck squamous cell carcinoma (HNSCC) has a large global burden of disease
and poor survival outcomes. Recent targeted therapies and immunotherapies have been …
and poor survival outcomes. Recent targeted therapies and immunotherapies have been …
[HTML][HTML] Germline variants in DNA repair genes are associated with young-onset head and neck cancer
The genetic predisposition to head and neck carcinomas (HNSCC) and how the known risk
factors (papillomavirus infection, alcohol, and tobacco consumption) contribute to the early …
factors (papillomavirus infection, alcohol, and tobacco consumption) contribute to the early …
Prevalence of DNA repair gene mutations in blood and tumor tissue and impact on prognosis and treatment in HNSCC
Simple Summary The DNA damage repair (DDR) gene profile is largely unexplored in head
and neck squamous cell cancer (HNSCC), leaving little known about the treatment of …
and neck squamous cell cancer (HNSCC), leaving little known about the treatment of …
Clinical implication of genetic intratumor heterogeneity for targeted therapy in head and neck cancer
Background Genomic profiling is increasingly used both in therapeutic decision-making and
as inclusion criteria for trials testing targeted therapies. However, the mutational landscape …
as inclusion criteria for trials testing targeted therapies. However, the mutational landscape …
The Wnt-driven Mll1 epigenome regulates salivary gland and head and neck cancer
Q Zhu, L Fang, J Heuberger, A Kranz, J Schipper… - Cell Reports, 2019 - cell.com
We identified a regulatory system that acts downstream of Wnt/β-catenin signaling in salivary
gland and head and neck carcinomas. We show in a mouse tumor model of K14-Cre …
gland and head and neck carcinomas. We show in a mouse tumor model of K14-Cre …
[HTML][HTML] Whole exome sequencing identifies mTOR and KEAP1 as potential targets for radiosensitization of HNSCC cells refractory to EGFR and β1 integrin inhibition
E Klapproth, E Dickreuter, F Zakrzewski, M Seifert… - Oncotarget, 2018 - ncbi.nlm.nih.gov
Intrinsic and acquired resistances are major obstacles in cancer therapy. Genetic
characterization is commonly used to identify predictive or prognostic biomarker signatures …
characterization is commonly used to identify predictive or prognostic biomarker signatures …
Lack of differences in radiation-induced immunogenicity parameters between HPV-positive and HPV-negative human HNSCC cell lines
K Schneider, V Bol, V Grégoire - Radiotherapy and Oncology, 2017 - Elsevier
Background and purpose Clinical studies indicate that patients with HPV/p16-associated
head & neck squamous cell carcinoma (HNSCC) represent a subgroup with a better …
head & neck squamous cell carcinoma (HNSCC) represent a subgroup with a better …
Whole-exome sequencing of sinonasal small cell carcinoma arising within a papillary schneiderian carcinoma in situ
J Smith, A Kulkarni, AC Birkeland… - … –Head and Neck …, 2018 - journals.sagepub.com
Objective The pathogenetic underpinnings of extrapulmonary small cell carcinomas
(EPSCCs) of the head and neck are poorly understood. We sought to describe the clinical …
(EPSCCs) of the head and neck are poorly understood. We sought to describe the clinical …