The fetal origins of mental illness
BJS Al-Haddad, E Oler, B Armistead… - American journal of …, 2019 - Elsevier
The impact of infections and inflammation during pregnancy on the developing fetal brain
remains incompletely defined, with important clinical and research gaps. Although the …
remains incompletely defined, with important clinical and research gaps. Although the …
Microbiome, inflammation, epigenetic alterations, and mental diseases
R Alam, HM Abdolmaleky… - American Journal of …, 2017 - Wiley Online Library
Major mental diseases such as autism, bipolar disorder, schizophrenia, and major
depressive disorder are debilitating illnesses with complex etiologies. Recent findings show …
depressive disorder are debilitating illnesses with complex etiologies. Recent findings show …
Critical evaluation of the Illumina MethylationEPIC BeadChip microarray for whole-genome DNA methylation profiling
Background In recent years the Illumina HumanMethylation450 (HM450) BeadChip has
provided a user-friendly platform to profile DNA methylation in human samples. However …
provided a user-friendly platform to profile DNA methylation in human samples. However …
Mapping DNA methylation across development, genotype and schizophrenia in the human frontal cortex
DNA methylation (DNAm) is important in brain development and is potentially important in
schizophrenia. We characterized DNAm in prefrontal cortex from 335 non-psychiatric …
schizophrenia. We characterized DNAm in prefrontal cortex from 335 non-psychiatric …
Interindividual methylomic variation across blood, cortex, and cerebellum: implications for epigenetic studies of neurological and neuropsychiatric phenotypes
Given the tissue-specific nature of epigenetic processes, the assessment of disease-relevant
tissue is an important consideration for epigenome-wide association studies (EWAS). Little …
tissue is an important consideration for epigenome-wide association studies (EWAS). Little …
An integrated genetic-epigenetic analysis of schizophrenia: evidence for co-localization of genetic associations and differential DNA methylation
Background Schizophrenia is a highly heritable, neuropsychiatric disorder characterized by
episodic psychosis and altered cognitive function. Despite success in identifying genetic …
episodic psychosis and altered cognitive function. Despite success in identifying genetic …
Guidance for DNA methylation studies: statistical insights from the Illumina EPIC array
Background There has been a steady increase in the number of studies aiming to identify
DNA methylation differences associated with complex phenotypes. Many of the challenges …
DNA methylation differences associated with complex phenotypes. Many of the challenges …
Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci
We characterized DNA methylation quantitative trait loci (mQTLs) in a large collection (n=
166) of human fetal brain samples spanning 56–166 d post-conception, identifying> 16,000 …
166) of human fetal brain samples spanning 56–166 d post-conception, identifying> 16,000 …
An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease
Background Epigenetic biomarkers of aging (the “epigenetic clock”) have the potential to
address puzzling findings surrounding mortality rates and incidence of cardio-metabolic …
address puzzling findings surrounding mortality rates and incidence of cardio-metabolic …
DNA methylation meta-analysis reveals cellular alterations in psychosis and markers of treatment-resistant schizophrenia
We performed a systematic analysis of blood DNA methylation profiles from 4483
participants from seven independent cohorts identifying differentially methylated positions …
participants from seven independent cohorts identifying differentially methylated positions …