Over the past two decades, research has identified extrasynaptic GABA A receptor
populations that enable neurons to sense the low ambient GABA concentrations present in …

Two-pore domain K+(K 2P) channels give rise to leak (also called background) K+ currents.
The well-known role of background K+ currents is to stabilize the negative resting …

The proper functioning of the adult mammalian brain relies on the orchestrated regulation of
neural activity by a diverse population of GABA (γ-aminobutyric acid)-releasing neurons …

Cl− channels reside both in the plasma membrane and in intracellular organelles. Their
functions range from ion homeostasis to cell volume regulation, transepithelial transport, and …

GABA-A receptors are the major inhibitory neurotransmitter receptors in the brain and are
the site of action of many clinically important drugs. These receptors are composed of five …

Most synaptic inputs are made onto the dendritic tree. Recent work has shown that dendrites
play an active role in transforming synaptic input into neuronal output and in defining the …

How do neurons develop, control, and maintain their electrical signaling properties in spite
of ongoing protein turnover and perturbations to activity? From generic assumptions about …

Electrical signaling in neurons is based on the operation of plasmalemmal ion pumps and
carriers that establish transmembrane ion gradients, and on the operation of ion channels …

Mutations in ion channels involved in the generation and termination of action potentials
constitute a family of molecular defects that underlie fatal cardiac arrhythmias in inherited …

The hippocampus is thought to automatically encode all experience, yet the vast majority of
our experiences are not remembered later. Although psychological theories have postulated …