Mechanical signalling affects multiple biological processes during development and in adult
organisms, including cell fate transitions, cell migration, morphogenesis and immune …

Numerous studies have demonstrated that endothelial cells are capable of undergoing
endothelial to mesenchymal transition (EndMT), a newly recognized type of cellular …

Systemic scleroderma (SSc) is one of the most complex systemic autoimmune diseases. It
targets the vasculature, connective tissue-producing cells (namely fibroblasts/myofibroblasts …

Here, we propose a new model for understanding the Warburg effect in tumor metabolism.
Our hypothesis is that epithelial cancer cells induce the Warburg effect (aerobic glycolysis) …

Fibroblasts are the most abundant “non-cancerous” cells in tumors. However, it remains
largely unknown how these cancer-associated fibroblasts (CAFs) promote tumor growth and …

Fibrotic diseases encompass a wide spectrum of clinical entities including systemic fibrotic
diseases such as systemic sclerosis, sclerodermatous graft versus host disease …

Angiogenesis is a critical process required for tumor progression. Newly formed blood
vessels provide nutrition and oxygen to the tumor contributing to its growth and …

We have previously shown that a loss of stromal Cav-1 is a biomarker of poor prognosis in
breast cancers. Mechanistically, a loss of Cav-1 induces the metabolic reprogramming of …

The fibrotic diseases encompass a wide spectrum of entities including such multisystemic
diseases as systemic sclerosis, nephrogenic systemic fibrosis and sclerodermatous graft …

Human fibrotic diseases constitute a major health problem worldwide owing to the large
number of affected individuals, the incomplete knowledge of the fibrotic process …