Epigenetic mechanisms in memory and cognitive decline associated with aging and Alzheimer's disease
Epigenetic mechanisms, which include DNA methylation, a variety of post-translational
modifications of histone proteins (acetylation, phosphorylation, methylation, ubiquitination …
modifications of histone proteins (acetylation, phosphorylation, methylation, ubiquitination …
Methylation multiplicity and its clinical values in cancer
X Dai, T Ren, Y Zhang, N Nan - Expert reviews in molecular …, 2021 - cambridge.org
Methylation at DNA, RNA and protein levels plays critical roles in many cellular processes
and is associated with diverse differentiation events, physiological activities and human …
and is associated with diverse differentiation events, physiological activities and human …
Histone H3 proline 16 hydroxylation regulates mammalian gene expression
Histone post-translational modifications (PTMs) are important for regulating various DNA-
templated processes. Here, we report the existence of a histone PTM in mammalian cells …
templated processes. Here, we report the existence of a histone PTM in mammalian cells …
Interrogating epigenetic mechanisms with chemically customized chromatin
Genetic and genomic techniques have proven incredibly powerful for identifying and
studying molecular players implicated in the epigenetic regulation of DNA-templated …
studying molecular players implicated in the epigenetic regulation of DNA-templated …
Superfast desulfurization for protein chemical synthesis and modification
Highly effective yet chemoselective chemical transformation strategies enable the facile
access and precise modification of complicated biomacromolecules. In particular, the …
access and precise modification of complicated biomacromolecules. In particular, the …
Nerves in gastrointestinal cancer: from mechanism to modulations
N Vaes, M Idris, W Boesmans, MM Alves… - Nature Reviews …, 2022 - nature.com
Maintenance of gastrointestinal health is challenging as it requires balancing multifaceted
processes within the highly complex and dynamic ecosystem of the gastrointestinal tract …
processes within the highly complex and dynamic ecosystem of the gastrointestinal tract …
Bioorthogonal labeling and enrichment of histone monoaminylation reveal its accumulation and regulatory function in cancer cell chromatin
Histone monoaminylation (ie., serotonylation and dopaminylation) is an emerging category
of epigenetic mark occurring on the fifth glutamine (Q5) residue of H3 N-terminal tail, which …
of epigenetic mark occurring on the fifth glutamine (Q5) residue of H3 N-terminal tail, which …
TGM2-mediated histone transglutamination is dictated by steric accessibility
BJ Lukasak, MM Mitchener, L Kong… - Proceedings of the …, 2022 - National Acad Sciences
Recent studies have identified serotonylation of glutamine-5 on histone H3 (H3Q5ser) as a
novel posttranslational modification (PTM) associated with active transcription. While …
novel posttranslational modification (PTM) associated with active transcription. While …
Histone H3 dopaminylation in ventral tegmental area underlies heroin-induced transcriptional and behavioral plasticity in male rats
Persistent transcriptional events in ventral tegmental area (VTA) and other reward relevant
brain regions contribute to enduring behavioral adaptations that characterize substance use …
brain regions contribute to enduring behavioral adaptations that characterize substance use …
Targeting epigenetics as a promising therapeutic strategy for treatment of neurodegenerative diseases
L Zhang, Y Liu, Y Lu, G Wang - Biochemical pharmacology, 2022 - Elsevier
Nowadays, epigenetics is of great research value as a new gateway that can solve the
sophisticated mysteries behind neurodegenerative diseases. Epigenetic mechanisms …
sophisticated mysteries behind neurodegenerative diseases. Epigenetic mechanisms …