Molecular aspects of gene transfer and foreign DNA acquisition in prokaryotes with regard to safety issues
M Brigulla, W Wackernagel - Applied microbiology and biotechnology, 2010 - Springer
Horizontal gene transfer (HGT) is part of prokaryotic life style and a major factor in evolution.
In principle, any combinations of genetic information can be explored via HGT for effects on …
In principle, any combinations of genetic information can be explored via HGT for effects on …
Integration of foreign DNA during natural transformation of Acinetobacter sp. by homology-facilitated illegitimate recombination
J de Vries, W Wackernagel - Proceedings of the National …, 2002 - National Acad Sciences
The active uptake of extracellular DNA and its genomic integration is termed natural
transformation and constitutes a major horizontal gene-transfer mechanism in prokaryotes …
transformation and constitutes a major horizontal gene-transfer mechanism in prokaryotes …
Amycolatopsis mediterranei: A Sixty-Year Journey from Strain Isolation to Unlocking Its Potential of Rifamycin Analogue Production by Combinatorial Biosynthesis
Ever since the isolation of Amycolatopsis mediterranei in 1957, this strain has been the
focus of research worldwide. In the last 60 years or more, our understanding of the …
focus of research worldwide. In the last 60 years or more, our understanding of the …
Identification of tailoring genes involved in the modification of the polyketide backbone of rifamycin B by Amycolatopsis mediterranei S699
Rifamycin B biosynthesis by Amycolatopsis mediterranei S699 involves a number of
unusual modification reactions in the formation of the unique polyketide backbone and …
unusual modification reactions in the formation of the unique polyketide backbone and …
Modification of rifamycin polyketide backbone leads to improved drug activity against rifampicin-resistant Mycobacterium tuberculosis
Rifamycin B, a product of Amycolatopsis mediterranei S699, is the precursor of clinically
used antibiotics that are effective against tuberculosis, leprosy, and AIDS-related …
used antibiotics that are effective against tuberculosis, leprosy, and AIDS-related …
Genomic modifications for enhanced antibiotic production in rifamycin derivative-producing Amycolatopsis mediterranei S699 strains: focusing on rifQ and rifO …
Rifamycin and its derivatives are natural products that belong to the class of antibiotic-active
polyketides and have significant therapeutic relevance within the therapy scheme of …
polyketides and have significant therapeutic relevance within the therapy scheme of …
Development of three different gene cloning systems for genetic investigation of the new species Amycolatopsis japonicum MG417-CF17, the …
E Stegmann, S Pelzer, K Wilken, W Wohlleben - Journal of biotechnology, 2001 - Elsevier
For the first time gene cloning systems have been developed for Amycolatopsis japonicum.
Direct transformation, polyethyleneglycol (PEG) induced protoplast transformation and …
Direct transformation, polyethyleneglycol (PEG) induced protoplast transformation and …
Regulation and manipulation of the gene clusters encoding type-I PKSs
Modular polyketide synthases are large, multifunctional enzyme complexes that are involved
in the biosynthesis of important polyketides. Recent studies have revolutionized our …
in the biosynthesis of important polyketides. Recent studies have revolutionized our …
Construction of expression vectors for metabolic engineering of the vanillin-producing actinomycete Amycolatopsis sp. ATCC 39116
C Fleige, A Steinbüchel - Applied microbiology and biotechnology, 2014 - Springer
Amycolatopsis sp. ATCC 39116 is able to synthesize the important flavoring agent vanillin
from cheap natural substrates. The bacterium is therefore of great interest for the industry …
from cheap natural substrates. The bacterium is therefore of great interest for the industry …
Synthetic biology in action: developing a drug against MDR-TB
The amalgamation of the research efforts of biologists, chemists and geneticists led by
scientists at the Department of Zoology, University of Delhi has resulted in the development …
scientists at the Department of Zoology, University of Delhi has resulted in the development …