Prion diseases are progressive, incurable and fatal neurodegenerative conditions. The term
'prion'was first nominated to express the revolutionary concept that a protein could be …

Proteolytic processing of the cellular and disease-associated form of the prion protein leads
to generation of bioactive soluble prion protein fragments and modifies the structure and …

Alzheimer's disease is a common neurodegenerative, progressive, and fatal disorder.
Generation and deposition of amyloid beta (Aβ) peptides associate with its pathogenesis …

In Alzheimer's disease, accumulation of soluble oligomers of β-amyloid peptide is known to
be highly toxic, causing disturbances in synaptic activity and neuronal death. Multiple …

Background Alzheimer's disease (AD) pathology occurs in part as the result of excessive
production of β-amyloid (Aβ). Metabotropic glutamate receptor 5 (mGluR5) is now …

We used Illumina Human HT-12 v4 arrays to compare RNA expression of middle temporal
gyrus (MTG; BA21) in Alzheimer's disease (AD= 97) and non-demented controls (ND= 98). A …

The prion protein (PrPC) is highly expressed in the nervous system and critically involved in
prion diseases where it misfolds into pathogenic PrPSc. Moreover, it has been suggested as …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the
presence of extracellular amyloid plaques consisting of Amyloid-β peptide (Aβ) aggregates …

Microglia and complements appear to be involved in the synaptic and cognitive deficits in
Alzheimer's disease (AD), though the mechanisms remain elusive. In this study, utilizing two …

In Alzheimer's disease (AD), soluble amyloid-β oligomers (AβOs) trigger neurotoxic
signaling, at least partially, via the cellular prion protein (PrPC). However, it is unknown …