Store-operated calcium (Ca2+) entry (SOCE) occurs through a widely distributed family of
ion channels activated by the loss of Ca2+ from the endoplasmic reticulum (ER). The best …

Abstract A primary calcium (Ca 2+) entry pathway into non-excitable cells is through the
store-operated Ca 2+ release activated Ca 2+(CRAC) channel. Ca 2+ entry into cells is …

Ca2+ entry into the cell via store-operated Ca2+ release-activated Ca2+ (CRAC) channels
triggers diverse signaling cascades that affect cellular processes like cell growth, gene …

We present a combination of force field and ab initio molecular dynamics simulations
together with neutron scattering experiments with isotopic substitution that aim at …

The calcium release-activated calcium channel Orai regulates Ca2+ entry into non-excitable
cells and is required for proper immune function. While the channel typically opens following …

Store‐operated Ca2+ entry through Orai1 channels is a primary mechanism for Ca2+ entry
in many cells and mediates numerous cellular effector functions ranging from gene …

ABSTRACT Calcium (Ca2+) is a physiological key factor, and the precise modulation of free
cytosolic Ca2+ levels regulates multiple cellular functions. Store‐operated Ca2+ entry …

The channel Orai1 requires Ca2+ store depletion in the endoplasmic reticulum and an
interaction with the Ca2+ sensor STIM1 to mediate Ca2+ signaling. Alterations in Orai1 …

Simple Summary Breast cancer shows a high heterogeneity which accounts for cancer
subtype aggressiveness. Store-operated calcium entry (SOCE) is significantly remodeled in …

Transient receptor potential melastatin 4 (TRPM4) is widely expressed in various organs
and associated with cardiovascular and immune diseases. Lately, the interest in studies on …