GABA A receptors are the major inhibitory transmitter receptors in the brain. They are ligand-
gated chloride channels and the site of action of benzodiazepines, barbiturates, neuroactive …

Abstract GABA A receptors (GABA A Rs) are a class of ligand-gated ion channels with high
physiological and therapeutic significance. In the brain, these pentameric receptors occur …

Type A γ-aminobutyric acid receptors (GABAARs) are pentameric ligand-gated chloride
channels that mediate fast inhibitory signalling in neural circuits, and can be modulated by …

γ-Aminobutyric acid type A receptors (GABAARs) are GABA gated heteropentameric
chloride channels responsible for the adult brain's primary inhibition. In specific brain cells …

Communication between nerve cells depends on the balance between excitatory and
inhibitory circuits. GABA, the major inhibitory neurotransmitter, regulates this balance and …

GABA A receptors play a dominant role in mediating inhibition in the mature mammalian
brain, and defects of GABAergic neurotransmission contribute to the pathogenesis of a …

Compounds that can act on GABAA receptor subtype in a selective manner, without the side
effects of classical benzodiazepine ligands, represent promising therapeutic tools in …

Extrasynaptic γ-aminobutyric acid type A receptors (GABA A Rs), which contribute
generalized inhibitory tone to the mammalian brain, are major targets for general …

Key points Physiologically relevant combinations of recombinant GABAA receptor (GABAR)
subunits were expressed in HEK293 cells. Using whole‐cell voltage clamp and rapid drug …

Decreased expression of the δ subunit of the GABA A receptor (GABA AR) has been found
in the dentate gyrus in several animal models of epilepsy and other disorders with increased …